NDLI: Predicting Outcome of Aortic Dissection with Patent False Lumen by Computational Flow Analysis

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Predicting Outcome of Aortic Dissection with Patent False Lumen by Computational Flow Analysis

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Predicting Outcome of Aortic Dissection with Patent False Lumen by Computational Flow Analysis

Content Provider	Springer Nature Link
Author	Rinaudo, Antonino D’Ancona, Giuseppe Lee, Jake J. Pilato, Gerlando Amaducci, Andrea Baglini, Roberto Follis, Fabrizio Pilato, Michele Pasta, Salvatore
Copyright Year	2014
Abstract	Although Type B aortic dissection (AoD) has better in-hospital survival than Type A AoD, the short- and long term outcome for patients remains challenging, with 50–80% deaths at 5-years. Dissection-related complications include rapid aortic expansion, impending rupture, and malperfusion syndromes. We aimed to assess hemodynamic implications of patients with patent false lumen (FL) of dissected aorta. Computational fluid dynamic analyses were performed on patient-specific aortic geometries reconstructed from computed tomography scans of 25 patients with AoDs, who were admitted in our hospital from 2007 to 2013. We used the development of acute complications and chronic aneurysmal evolution as patient endpoints. Anatomical variables were correlated with hemodynamic variables, and regression was then performed to show independent determinants of FL flow. Velocity streamlines revealed helical, slower-moving flow in the FL of AoDs. Blood pressure and wall shear stress varied markedly between subjects, depending on AoD geometry. Lastly, linear regression shown that the height of entry tears was a significant predictor of blood flow through the patent FL. The greater the entry tear is, the greater the flow in the patent FL and thus the risk of dissection-related complications. Computational flow analysis may lead to more confident predictions of which patients will suffer adverse events and facilitate the clinical decision-making process related to the treatment of Type B AoDs.
Starting Page	176
Ending Page	188
Page Count	13
File Format	PDF
ISSN	1869408X
Journal	Cardiovascular Engineering and Technology
Volume Number	5
Issue Number	2
e-ISSN	18694098
Language	English
Publisher	Springer US
Publisher Date	2014-05-01
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Type B aortic dissection CFD False lumen Flow Biomedical Engineering Cardiology Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering Cardiology and Cardiovascular Medicine

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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