NDLI: Targeted doxorubicin delivery based on avidin-biotin technology in cervical tumor cells

Content Provider	Springer Nature Link
Author	Park, Seong Cheol Kim, Young Min Kim, Nam Hong Kim, Eun Ji Park, Yung Hoon Lee, Jung Ro Jang, Mi Kyeong
Copyright Year	2017
Abstract	Targeting antitumor drugs to specific tissues or cells has attracted considerable interest in the recent tumor therapy because it can reduce the side effects in the body and the treated drug dosage through homing drug to the desired tissues. To utilize the high affinity of biotin to avidin as a drug carrier for doxorubicin (DOX), biotinylated targeting material (biotin-polyethylene glycol (PEG)-folic acid, BPF) and biotinylated drug with a bioreducible linker (biotin-SS-PEG-DOX, BSPD) were designed in this study. The in vitro cellular uptake of the avidin/biotinylated drug complexes showed that the complexes with BPF were internalized dose-dependently into HeLa cells, while their uptake was not detected in the absence of BPF. Although the anti-tumor activity of the drug complexes with BPF and BSPD were similar to that of free DOX in cervical cancer cells, the cytotoxic effect of DOX was significantly reduced in normal cells. Their targeting antitumor effect revealed the significant inhibition of the increasing tumor size in HeLa-xenograft mouse model. These results show that the strong complexing between avidin and biotin acted as a targeting moiety and the antitumor drug is an adaptable tool in the fields of tumor therapy.
Starting Page	882
Ending Page	889
Page Count	8
File Format	PDF
ISSN	15985032
Journal	Macromolecular Research
Volume Number	25
Issue Number	9
e-ISSN	20927673
Language	English
Publisher	The Polymer Society of Korea
Publisher Date	2017-07-29
Publisher Place	Seoul
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	avidin biotin cervical cancer doxorubicin folic acid xenograft Polymer Sciences Soft and Granular Matter, Complex Fluids and Microfluidics Physical Chemistry Characterization and Evaluation of Materials Nanochemistry Nanotechnology
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Materials Chemistry Chemical Engineering Polymers and Plastics

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