NDLI: Polymeric tube-shaped devices with controlled geometry for programmed drug delivery

Content Provider	Springer Nature Link
Author	Park, Min Park, Chun Gwon Lee, Seung Ho Lee, Ji Eun Cho, Eunbit Prausnitz, Mark R. Choy, Young Bin
Copyright Year	2012
Abstract	We developed a modular tube-shaped device as a proof of principle to enable the programmed release of encapsulated molecules for controlled drug delivery. Each drug-delivery tube module was prepared by assembling two separate silicone tubes in a series, one filled with a model compound (sodium fluorescein) and the other with a diffusional barrier material (polyethylene oxide, PEO). We varied the length of the PEO-filled tubes to control the release from the drug-delivery tube devices. The onset times and periods of drug release increased with the length of the PEO tube. To program the drug release, therefore, we prepared devices with combinations of drug-delivery tube modules with different lengths of PEO-filled tubes. Using PEO-filled tubes with very different lengths achieved a pulsatile drug release while a continuous drug release was realized by using PEO-filled tubes with small differences in length. We concluded that the modular combination of drug-delivery tubes, each composed of a diffusionbarrier tube of different length, demonstrates good potential for applications in programmed drug delivery.
Starting Page	960
Ending Page	967
Page Count	8
File Format	PDF
ISSN	15985032
Journal	Macromolecular Research
Volume Number	20
Issue Number	9
e-ISSN	20927673
Language	English
Publisher	The Polymer Society of Korea
Publisher Date	2012-06-05
Publisher Place	Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	continuous drug release drug-delivery tube polyethylene oxide (PEO) programmed drug delivery pulsatile drug silicone Physical Chemistry Polymer Sciences Characterization and Evaluation of Materials Nanotechnology Soft and Granular Matter, Complex Fluids and Microfluidics Nanochemistry
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Materials Chemistry Chemical Engineering Polymers and Plastics

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