NDLI: Synthesis of O-carboxylated low molecular chitosan with azido phenyl group: Its application for adhesion prevention

Content Provider	Springer Nature Link
Author	Na, Ha Na Kim, Kwang Il Han, Jae Hong Lee, Jae Gwan Son, Tae Il Han, Dong Keun Ito, Yoshihiro Song, Kwang Sup Jang, Eui Chan
Copyright Year	2010
Abstract	A water-soluble photo-reactive chitosan derivative was synthesized as a novel anti-adhesive agent by combining low molecular O-carboxymethyl chitosan and photo-reactive N-(4-azidobenzoyloxy) succinimide. Photoreactive low molecular O-carboxymethyl chitosan was analyzed by Fourier transform infrared spectroscopy (FTIR) and proton nuclear resonance spectroscopy ($^{1}$H NMR). Photo-immobilization of the polymer was confirmed using photo-mask and the degree of cross-linking was measured from the immobilized dried weight. The cytotoxicity of the photo-reactive low molecular O-carboxymethyl chitosan was confirmed by a MTT assay. In vivo animal study was performed to identify the synthetic material for antiadhesive effect. Furthermore, the protein release test that was performed to apply it as a drug-eluting anti-adhesive agent after bovine serum albumin (BSA), was immobilized to the photoreactive polymer. Because photo-reactive low molecular O-carboxymethyl chitosan has high water solubility as well as non-cytotoxicity and photoimmobilization, it may a suitable material for making drug-eluting antiadhesive agents.
Starting Page	1001
Ending Page	1007
Page Count	7
File Format	PDF
ISSN	15985032
Journal	Macromolecular Research
Volume Number	18
Issue Number	10
e-ISSN	20927673
Language	English
Publisher	The Polymer Society of Korea
Publisher Date	2010-11-23
Publisher Place	Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	photo-immobilization O-carboxymethyl chitosan anti-adhesive agent drugeluting Nanotechnology Nanochemistry Characterization and Evaluation of Materials Physical Chemistry Soft and Granular Matter, Complex Fluids and Microfluidics Polymer Sciences
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Materials Chemistry Chemical Engineering Polymers and Plastics

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