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| Content Provider | Springer Nature Link |
|---|---|
| Author | Ozbalci, Çağakan Unsal, Çağlayan Kazan, Dilek Sariyar Akbulut, Berna |
| Copyright Year | 2010 |
| Abstract | The cellular response of Escherichia coli exposed to alkaloids extracted from a biennial endemic plant, Papaver polychaetum, was explored using proteome analysis. Following determination of the minimum inhibitory concentration of the berberine-containing plant extract as 1,250 μg/mL, E. coli cells were grown in the presence of 750 μg/mL extract. The response of the bacteria to the extract, with berberine found as the major alkaloid, was analyzed on two-dimensional gels. The differentially expressed proteins in the presence of 750 μg/mL extract were identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry. These proteins included those that play vital roles for maintenance such as protein synthesis (elongation factor-Ts), transport (oligopeptide-binding protein A, uncharacterized amino-acid ABC transporter ATP binding protein YECC), energy metabolism (alpha-subunit of ATP synthase, pyridine nucleotide transhydrogenase STHA) and regulation. These results provide clues for understanding the mechanism of the alkaloid extract-induced stress and cytotoxicity on E. coli. The altered proteins can serve as potential targets for development of innovative therapeutic agents. |
| Starting Page | 709 |
| Ending Page | 717 |
| Page Count | 9 |
| File Format | |
| ISSN | 15904261 |
| Journal | Annals of Microbiology |
| Volume Number | 60 |
| Issue Number | 4 |
| e-ISSN | 18692044 |
| Language | English |
| Publisher | Springer-Verlag |
| Publisher Date | 2010-08-31 |
| Publisher Place | Berlin, Heidelberg |
| Access Restriction | Subscribed |
| Subject Keyword | Proteomics Antimicrobial Escherichia coli Papaver polychaetum Berberine Applied Microbiology Medical Microbiology Fungus Genetics Microbial Ecology Microbial Genetics and Genomics Microbiology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Applied Microbiology and Biotechnology |
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