NDLI: Hepatic proteome responses against benz[a]anthracene in the rat

Content Provider	Springer Nature Link
Author	Park, Seul Ki Seo, Yoo Na Nam, Suk Woo Lee, Mi Young
Copyright Year	2011
Abstract	Benz[a]anthracene (B[a]A) is one of the most ubiquitous polycyclic aromatic hydrocarbons and environmental pollutants. Mass spectrometrybased proteomics was used to characterize changes in the liver proteome in response to B[a]A exposure. Nine hepatic protein spots were identified that exhibited B[a]A-induced significant expression changes. Of these, six were up-regulated and the rest were downregulated by B[a]A at 10% of its LD50. At 50% of the LD$_{50}$ of B[a]A, five proteins were up-regulated while the rest were down-regulated. The proteomic results were also consistent with those obtained by western blot. The differential expressions of these proteins may allow them to serve as biomarker candidates for B[a]A toxicity.
Starting Page	309
Ending Page	316
Page Count	8
File Format	PDF
ISSN	19760280
Journal	BioChip Journal
Volume Number	5
Issue Number	4
e-ISSN	20927843
Language	English
Publisher	The Korean BioChip Society (KBCS)
Publisher Date	2011-12-20
Publisher Place	Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Benz[a]anthracene Rat Liver Proteomics Differential proteins Biotechnology Biomedical Engineering
Content Type	Text
Resource Type	Article
Subject	Bioengineering Biomedical Engineering Electrical and Electronic Engineering Biotechnology

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Hepatic proteome responses against benz[a]anthracene in the rat