NDLI: Disrupted pathways associated with neonatal sepsis: Combination of protein-protein interactions and pathway data

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BioChip Journal : Volume 11, Issue 2, June 2017

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Disrupted pathways associated with neonatal sepsis: Combination of protein-protein interactions and pathway data

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Disrupted pathways associated with neonatal sepsis: Combination of protein-protein interactions and pathway data

Content Provider	Springer Nature Link
Author	Qiao, Xin Zhu, Silian Zhang, Shujiao Dong, Hongmei
Copyright Year	2016
Abstract	To identify disrupted pathways associated with neonatal sepsis, we performed a research based on the combination of protein-protein interactions (PPIs) and pathway data. Firstly, a total of 23,292 genes, 787,896 PPIs and 1,675 human pathways were obtained, respectively. Then, under the threshold value of false discovery rate (FDR)<0.05 and a delta cut-off value >4.36, a total of 986 differentially expressed genes (DEGs) were identified. In the following, by degree centrality for the objective PPI network, 20 hub genes were obtained. Finally, pathway enrichment analysis and randomization tests indicated that pathways of gene expression, immune system and innate immune system were with remarkable significance in neonatal sepsis. Therefore, in the present study, we presented a novel pathway method, and we successfully identified several pathways in neonatal sepsis, which might be underlying indicators in the detection and treatment of neonatal sepsis.
Starting Page	1
Ending Page	7
Page Count	7
File Format	PDF
ISSN	19760280
Journal	BioChip Journal
Volume Number	11
Issue Number	1
e-ISSN	20927843
Language	English
Publisher	The Korean BioChip Society (KBCS)
Publisher Date	2016-04-29
Publisher Place	Seoul
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Neonatal sepsis Hub gene Differentially expressed genes Protein-protein interaction Pathway Biotechnology Biomedical Engineering
Content Type	Text
Resource Type	Article
Subject	Bioengineering Biomedical Engineering Electrical and Electronic Engineering Biotechnology

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