NDLI: MicroRNA microarray analysis of human umbilical vein endothelial cells exposed to benzo(a)pyrene

Content Provider	Springer Nature Link
Author	Jeong, Seong Il Lee, Seung Eun Yang, Hana Park, Cheung Seog Cho, Jeong Je Park, Yong Seek
Copyright Year	2012
Abstract	MicroRNAs (miRNAs) are small non-coding RNA molecules that function as potent negative regulators of gene expression. They play a critical role in the regulation of genes involved in the cellular and molecular responses to toxicants. Benzo(a)pyrene (BaP) is an environmental contaminant found in cigarette smoke and is one of the polycyclic aromatic hydrocarbons (PAHs). BaP is considered a major contributor of vascular disease. In this study, we investigated whether miRNAs play a role in regulation of various gene expression responses to BaP in human umbilical vein endothelial cells (HUVECs). We performed a pair-wise correlation coefficient analysis on expression levels of 105 miRNAs and 2335 mRNA, and observed anti-correlations between miRNA and mRNA. The Gene Ontology enrichment analysis on the differential expression of miRNA-related genes revealed significant enrichment in the biological processes and signaling pathways. Our results first revealed the expression profiling of miRNAs in endothelial cells and contribute to the improvement of vascular disease.
Starting Page	191
Ending Page	196
Page Count	6
File Format	PDF
ISSN	19760280
Journal	BioChip Journal
Volume Number	6
Issue Number	2
e-ISSN	20927843
Language	English
Publisher	The Korean BioChip Society (KBCS)
Publisher Date	2012-06-20
Publisher Place	Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Benzo(a)pyrene microRNA Gene expression profile Vascular disease Endothelial cells Biotechnology Biomedical Engineering
Content Type	Text
Resource Type	Article
Subject	Bioengineering Biomedical Engineering Electrical and Electronic Engineering Biotechnology

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