NDLI: The toxicogenomic study on Persistent Organic Pollutants (POPs) in human hepatoma cell line

Content Provider	Springer Nature Link
Author	Choi, Han Saem Song, Mi Kyung Lee, EunIl Ryu, Jae Chun
Copyright Year	2013
Abstract	Persistent organic pollutants (POPs) are a major group of contaminants. They are geographically widely distributed, circulate globally, and remain intact in the environment for a long period. POPs accumulate particularly in the fatty tissue of living organisms. Although many chemicals are suspected to have hazardous effects, evaluation of their toxicities remains difficult and challenging. In this study, we used toxicogenomic tools that are simple and economical, as compared to other tools of risk assessment. To predict the risk of environmental toxic substances or compounds, investigation of toxicological mechanisms or biomarkers is important. In this study, we identified hepatotoxicity-related genes induced by three POPs (chlordane, toxaphene, and mirex) in the human hepatocellular carcinoma (HepG2) cell line using microarray and gene ontology (GO) analyses. Using microarray analyses, we identified genes that were up- and down-regulated by greater than 1.5-fold. After the GO analyses, we determined several key pathways that are known to be related to hepatotoxicity, including the metabolism of xenobiotics by apoptosis, complement and coagulation cascades, and cell cycle regulation. Thus, our present study suggests that differentially expressed genes by POPs may provide clues for the hepatotoxic mechanism of POPs. In addition, gene expression profiling by toxicogenomic analyses also affords promising opportunities to reveal new toxicity mechanistic markers.
Starting Page	17
Ending Page	28
Page Count	12
File Format	PDF
ISSN	19760280
Journal	BioChip Journal
Volume Number	7
Issue Number	1
e-ISSN	20927843
Language	English
Publisher	The Korean BioChip Society (KBCS)
Publisher Date	2013-03-20
Publisher Place	Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Persistent Organic Pollutants (POPs) Chlordane Toxaphene Mirex Microarray Gene ontology (GO) Biotechnology Biomedical Engineering
Content Type	Text
Resource Type	Article
Subject	Bioengineering Biomedical Engineering Electrical and Electronic Engineering Biotechnology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Dose-response analysis of the effects of persistent organic pollutants (POPs) on gene expression in human hepatocytes

Analysis of differentially expressed genes by Mirex ‘persistent organic pollutant’ in HepG2 cells

Identification of hepatotoxicity related genes induced by chlordane in human hepatocellular carcinoma (HepG2) cells

Identification of hepatotoxicity related genes induced by toxaphene in HepG2 cells

Comparative study on transcriptional responses of human neuronal cells to silica nanoparticles with different stabilizers

Epigenetic Regulation of miR-22 in a BPA-exposed Human Hepatoma Cell

DNA microarray analysis of gene expression profiles in Caenorhabditis elegans exposed to cadmium

Gene expression profiling associated with treatment of positive charged colloidal silica nanoparticle in human neuroblastoma cells

Genome-wide expression profiling of carbaryl and vinclozolin in human thyroid follicular carcinoma (FTC-238) cells

The toxicogenomic study on Persistent Organic Pollutants (POPs) in human hepatoma cell line

Similar Documents

Dose-response analysis of the effects of persistent organic pollutants (POPs) on gene expression in human hepatocytes

Analysis of differentially expressed genes by Mirex ‘persistent organic pollutant’ in HepG2 cells

Identification of hepatotoxicity related genes induced by chlordane in human hepatocellular carcinoma (HepG2) cells

Identification of hepatotoxicity related genes induced by toxaphene in HepG2 cells

Comparative study on transcriptional responses of human neuronal cells to silica nanoparticles with different stabilizers

Epigenetic Regulation of miR-22 in a BPA-exposed Human Hepatoma Cell

DNA microarray analysis of gene expression profiles in Caenorhabditis elegans exposed to cadmium

Gene expression profiling associated with treatment of positive charged colloidal silica nanoparticle in human neuroblastoma cells

Genome-wide expression profiling of carbaryl and vinclozolin in human thyroid follicular carcinoma (FTC-238) cells

The toxicogenomic study on Persistent Organic Pollutants (POPs) in human hepatoma cell line