NDLI: Genomewide transcription profiles altered by BMI-1026 and Roscovitine and its implication in cellular senescence

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Genomewide transcription profiles altered by BMI-1026 and Roscovitine and its implication in cellular senescence

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Genomewide transcription profiles altered by BMI-1026 and Roscovitine and its implication in cellular senescence

Content Provider	Springer Nature Link
Author	Lee, Ji Hye Min, Changhee Kwak, Sahng June Seong, Yeon Sun
Copyright Year	2012
Abstract	Cyclin-dependent kinases (CDKs) are highly conserved over evolutionary path and function as master regulators of the cell division cycle. Thus CDK inhibitors have been focused in the drug development for cancer and other cell proliferative disorders. Among these inhibitors Roscovitine is well known compound and under clinical trial currently while far less has been reported on another CDK inhibitor — BMI-1026, designed as a drug candidate also targeting the cell cycle. In this study we tried to define biological effects and possible mechanisms of the two chemicals by analyzing the altered transcriptome profiles when BMI-1026 and Roscovitine are applied on WI-38 cells. Our result revealed both BMI-1026 and Roscovitine produced similar gene expression profiles, where E2F target genes were suppressed in common, including cyclin A, MCM3 and PCNA along with activated p53 pathway. This finding strongly indicates that molecular machineries responsible for other established senescence models are also employed in the changes in WI-38 cells induced by the two CDK inhibitors.
Starting Page	362
Ending Page	371
Page Count	10
File Format	PDF
ISSN	19760280
Journal	BioChip Journal
Volume Number	6
Issue Number	4
e-ISSN	20927843
Language	English
Publisher	The Korean BioChip Society (KBCS)
Publisher Date	2012-12-20
Publisher Place	Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	CDK inhibitor BMI-1026 Roscovitine E2F target genes Senescence Biotechnology Biomedical Engineering
Content Type	Text
Resource Type	Article
Subject	Bioengineering Biomedical Engineering Electrical and Electronic Engineering Biotechnology

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