NDLI: Phenolics of pomegranate peels: extraction optimization by central composite design and alpha glucosidase inhibition potentials

Content Provider	Springer Nature Link
Author	Çam, Mustafa İçyer, Necattin Cihat
Copyright Year	2013
Abstract	Optimum water extraction conditions for phenolics of pomegranate peels were investigated by fractional factorial and face-centered central composite designs. Five potential factors were selected for the fractional factorial design: extraction technique, extraction temperature, extraction time, particle size and solvent to solid ratio. After eliminating statistically unimportant factors, a face-centered central composite design was set up with two controllable factors and with two responses: total phenolics and α-glucosidase inhibition activity. Optimum conditions were found as 100 °C for extraction temperature and 1 min for extraction time. There were no statistically significant differences (p > 0.05) between water extracts at optimized conditions and classical methanol extracts. Total phenolic content by HPLC was192.0 mg/g of pomegranate peels on dry matter basis. Phenolics of pomegranate peels showed α-glucosidase inhibition activity with an IC$_{50}$ (concentration of phenolics required to inhibit 50 % of the enzyme activity) value of 5.56 ± 2.23 μg/ml. Pomegranate peel phenolics with its antioxidant and α-glucosidase inhibition properties might be a suitable ingredient for functional food applications.
Starting Page	1489
Ending Page	1497
Page Count	9
File Format	PDF
ISSN	00221155
Journal	Journal of Food Science and Technology
Volume Number	52
Issue Number	3
e-ISSN	09758402
Language	English
Publisher	Springer India
Publisher Date	2013-08-15
Publisher Place	India
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Pomegranate peel Central composite design Fractional factorial design Alpha glucosidase inhibition Food Science Nutrition Chemistry/Food Science
Content Type	Text
Resource Type	Article
Subject	Food Science

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Phenolics of pomegranate peels: extraction optimization by central composite design and alpha glucosidase inhibition potentials.

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