NDLI: Ideal cardiovascular health and liver enzyme levels in European adolescents; the HELENA study

Content Provider	Springer Nature Link
Author	Labayen, Idoia Ruiz, Jonatan R. Huybrechts, Inge Ortega, Francisco B. Castillo, Manuel Sjöstrom, Michael González Gross, Marcela Manios, Yannis Widhalm, Kurt Kafatos, Anthony Breidenassel, Christina Rodríguez, Gerardo Dallongeville, Jean Gottrand, Frédéric Moreno, Luis A.
Copyright Year	2017
Abstract	There is an increasing interest for the role of liver enzymes as predictors of non-liver-related morbidity and mortality. The American Heart Association (AHA) described the ideal cardiovascular health concept as a score of seven cardiovascular health behaviors and factors that can be used to monitor and predict ideal cardiovascular health over time. This study aimed to examine the association of the ideal cardiovascular health (ICH), as defined by the AHA, with liver enzyme levels in European adolescents. A total of 637 adolescents (54.6% females), aged 14.6 ± 1.2 years from nine European countries participated in this cross-sectional study. Blood levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyltransferase were measured and the AST/ALT ratio calculated. Ideal cardiovascular health was defined as meeting ideal levels of the following components: four behaviors (smoking, body mass index, physical activity, and diet) and three factors (total cholesterol, blood pressure, and glucose). A higher number of ideal cardiovascular health behaviors, factors, and ideal cardiovascular health index were associated with lower ALT (P < 0.05, P < 0.001, and P < 0.001, respectively) and gamma-glutamyltransferase (P < 0.001, P < 0.01, and P < 0.001, respectively) levels. Similarly, a higher number of ideal cardiovascular health behaviors (P < 0.01), factors (P < 0.01), and ideal cardiovascular health index (P < 0.001) were associated with a higher aspartate aminotransferase to alanine aminotransferase ratio. These findings reinforce the usefulness of the ICH index as an instrument to identify target individuals and promote cardiovascular health in adolescents, and it also extends these observations to the liver manifestation of the metabolic syndrome.
Starting Page	225
Ending Page	234
Page Count	10
File Format	PDF
ISSN	11387548
Journal	Journal of Physiology and Biochemistry
Volume Number	73
Issue Number	2
e-ISSN	18778755
Language	English
Publisher	Springer Netherlands
Publisher Date	2017-01-06
Publisher Institution	University of Navarra, Spain
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Ideal cardiovascular health (ICH) Liver enzymes Adolescents Biomedicine Human Physiology Animal Physiology
Content Type	Text
Resource Type	Article
Subject	Physiology Medicine Biochemistry

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