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| Content Provider | Springer Nature Link |
|---|---|
| Author | Rivas, C. I. Zúñiga, F. A. Salas Burgos, A. Mardones, L. Ormazabal, V. Vera, J. C. |
| Copyright Year | 2008 |
| Abstract | Vitamin C is a wide spectrum antioxidant essential for humans, which are unable to synthesize the vitamin and must obtain it from dietary sources. There are two biologically important forms of vitamin C, the reduced form, ascorbic acid, and the oxidized form, dehydroascorbic acid. Vitamin C exerts most of its biological functions intracellularly and is acquired by cells with the participation of specific membrane transporters. This is a central issue because even in those species capable of synthesizing vitamin C, synthesis is restricted to the liver (and pancreas) from which is distributed to the organism. Most cells express two different transproter systems for vitamin C; a transporter system with absolute specificity for ascorbic acid and a second system that shows absolute specificity for dehydroascorbic acid. The dehydroascorbic acid transporters are members of the GLUT family of facilitative glucose transporters, of which at least three isoforms, GLUT1, GLUT3 and GLUT4, are dehydroascorbic acid transporters. Ascorbic acid is transported by the SVCT family of sodium-coupled transporters, with two isoforms molecularly cloned, the transporters SVCT1 y SVCT2, that show different functional properties and differential cell and tissue expression. In humans, the maintenance of a low daily requirement of vitamin C is attained through an efficient system for the recycling of the vitamin involving the two families of vitamin C transporters. |
| Starting Page | 357 |
| Ending Page | 375 |
| Page Count | 19 |
| File Format | |
| ISSN | 11387548 |
| Journal | Journal of Physiology and Biochemistry |
| Volume Number | 64 |
| Issue Number | 4 |
| e-ISSN | 18778755 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2008-01-01 |
| Publisher Institution | University of Navarra, Spain |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Vitamin C Ascorbic acid Dehydroascorbic acid SVCT GLUT Biomedicine general Human Physiology Animal Physiology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology Medicine Biochemistry |
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