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  1. Journal of Physiology and Biochemistry
  2. Journal of Physiology and Biochemistry : Volume 64
  3. Journal of Physiology and Biochemistry : Volume 64, Issue 4, December 2008
  4. Vitamin C transporters
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Journal of Physiology and Biochemistry : Volume 64
Journal of Physiology and Biochemistry : Volume 64, Issue 4, December 2008
22$^{th}$ Meeting European Intestinal Transport Group
Nutrient sensing in the gastrointestinal tract: Possible role for nutrient transporters
Vitamin C transporters
Lipid raft organization and function in the small intestinal brush border
An introductory commentary
De Fabrica et Actione villorum intestinorum tenuium Hominis
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Vitamin C transporters

Content Provider Springer Nature Link
Author Rivas, C. I. Zúñiga, F. A. Salas Burgos, A. Mardones, L. Ormazabal, V. Vera, J. C.
Copyright Year 2008
Abstract Vitamin C is a wide spectrum antioxidant essential for humans, which are unable to synthesize the vitamin and must obtain it from dietary sources. There are two biologically important forms of vitamin C, the reduced form, ascorbic acid, and the oxidized form, dehydroascorbic acid. Vitamin C exerts most of its biological functions intracellularly and is acquired by cells with the participation of specific membrane transporters. This is a central issue because even in those species capable of synthesizing vitamin C, synthesis is restricted to the liver (and pancreas) from which is distributed to the organism. Most cells express two different transproter systems for vitamin C; a transporter system with absolute specificity for ascorbic acid and a second system that shows absolute specificity for dehydroascorbic acid. The dehydroascorbic acid transporters are members of the GLUT family of facilitative glucose transporters, of which at least three isoforms, GLUT1, GLUT3 and GLUT4, are dehydroascorbic acid transporters. Ascorbic acid is transported by the SVCT family of sodium-coupled transporters, with two isoforms molecularly cloned, the transporters SVCT1 y SVCT2, that show different functional properties and differential cell and tissue expression. In humans, the maintenance of a low daily requirement of vitamin C is attained through an efficient system for the recycling of the vitamin involving the two families of vitamin C transporters.
Starting Page 357
Ending Page 375
Page Count 19
File Format PDF
ISSN 11387548
Journal Journal of Physiology and Biochemistry
Volume Number 64
Issue Number 4
e-ISSN 18778755
Language English
Publisher Springer Netherlands
Publisher Date 2008-01-01
Publisher Institution University of Navarra, Spain
Publisher Place Dordrecht
Access Restriction One Nation One Subscription (ONOS)
Subject Keyword Vitamin C Ascorbic acid Dehydroascorbic acid SVCT GLUT Biomedicine general Human Physiology Animal Physiology
Content Type Text
Resource Type Article
Subject Physiology Medicine Biochemistry
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