NDLI: Toxic effects of cadmium on GABA and taurine content in different brain areas of adult male rats

Please wait, while we are loading the content...

Toxic effects of cadmium on GABA and taurine content in different brain areas of adult male rats

Content Provider	Springer Nature Link
Author	Lafuente, A. González Carracedo, A. Cabaleiro, T. Romero, A. Esquifino, A. I.
Copyright Year	2005
Abstract	This work assesses the possible changes in gamma amino butyric acid (GABA) and taurine content in the hypothalamus, the median eminence and striatum after the exposure to various doses of cadmium. Cadmium chloride (CdCl$_{2}$) was administered in the drinking water at the doses of 5, 10, 25, 50 or 100 ppm to adult male rats for 1 month. In the anterior hypothalamus, taurine and GABA content decreased with the dose of 10 ppm of CdCl$_{2}$ only. Cadmium exposure decreased both GABA and taurine content in mediobasal hypothalamus except for the 50 ppm dose. In posterior hypothalamus GABA and taurine content was not affected by cadmium treatment. As far as the median eminence, 5 or 10 ppm of CdCl$_{2}$ increased taurine concentration, and at a dose of 5 ppm enhanced GABA content. A significant decrease of GABA and taurine concentration was seen in the striatum at any dose of cadmium used. The concentration of cadmium increased in the hypothalamus and in the striatum in animals receiving CdCl$_{2}$ in the drinking water at doses of 25, 50 or 100 ppm. The results indicate that cadmium globally decreased GABA and taurine content in the brain areas studied through effects that were not dose dependent.En este trabajo se evalúan las posibles alteraciones en el contenido de ácido gamma amino butírico (GABA) y taurina, inducidas por varias dosis de cadmio en el hipotálamo, la eminencia media y el estriado. Para ello, se administró cloruro de cadmio (CdCl$_{2}$) durante 30 días a ratas macho adultas en el agua de bebida a las dosis de 5, 10, 25, 50 ó 100 ppm. En el hipotálamo anterior, la exposición al cadmio no modificó el contenido de taurina y GABA, aunque la concentración de estos aminoácidos descendió con las dosis de 10 ppm. Tanto el contenido de GABA como el de taurina disminuyeron significativamente en el hipotálamo mediobasal tras la exposición al cadmio, excepto con la dosis de 50 ppm. Sin embargo, en el hipotálamo posterior, la exposición a este metal no alteró los niveles de GABA y taurina. En la eminencia media, las dosis de 5 y 10 ppm aumentaron la concentración de taurina, mientras que el contenido de GABA sólo aumentó con la dosis de 5 ppm. Tras la exposición al cadmio, se observó un descenso en el contenido de GABA y taurina en el estriado con todas las dosis utilizadas. La concentración de cadmio aumentó en el hipotálamo y en el estriado con las dosis de 25, 50 y 100 ppm de CdCl$_{2}$. Globalmente, según estos resultados, la exposición al cadmio puede conllevar un descenso de GABA y taurina en las regiones cerebrales estudiadas, aunque dichos descenso no parece ser dependiente de las dosis del metal.
Starting Page	439
Ending Page	446
Page Count	8
File Format	PDF
ISSN	11387548
Journal	Journal of Physiology and Biochemistry
Volume Number	61
Issue Number	3
e-ISSN	18778755
Language	Spanish
Publisher	Springer Netherlands
Publisher Date	2005-01-01
Publisher Institution	University of Navarra, Spain
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cadmium Oral exposure GABA Taurine Human Physiology Biomedicine general Biochemistry Animal Physiology
Content Type	Text
Resource Type	Article
Subject	Physiology Medicine Biochemistry

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Hematological, immunological and neurochemical effects of chronic amphetamine treatment in male rats

Changes in UCP expression in tissues of Zucker rats fed diets with different protein content

Cadmium effects on dopamine turnover and plasma levels of prolactin, GH and ACTH

Influence of type II 5′ deiodinase on TSH content in diabetic rats

Effects of oral administration of benzylamine on glucose tolerance and lipid metabolism in rats

Effect of cadmium on lymphocyte subsets distribution in thymus and spleen

Probable gamma-aminobutyric acid involvement in bisphenol A effect at the hypothalamic level in adult male rats

Cadmium effects on 24h changes in glutamate, aspartate, glutamine, GABA and taurine content of rat striatum.

Effects of chronic insulin treatment on blood pressure in rats

Toxic effects of cadmium on GABA and taurine content in different brain areas of adult male rats

Similar Documents

Hematological, immunological and neurochemical effects of chronic amphetamine treatment in male rats

Changes in UCP expression in tissues of Zucker rats fed diets with different protein content

Cadmium effects on dopamine turnover and plasma levels of prolactin, GH and ACTH

Influence of type II 5′ deiodinase on TSH content in diabetic rats

Effects of oral administration of benzylamine on glucose tolerance and lipid metabolism in rats

Effect of cadmium on lymphocyte subsets distribution in thymus and spleen

Probable gamma-aminobutyric acid involvement in bisphenol A effect at the hypothalamic level in adult male rats

Cadmium effects on 24h changes in glutamate, aspartate, glutamine, GABA and taurine content of rat striatum.

Effects of chronic insulin treatment on blood pressure in rats

Toxic effects of cadmium on GABA and taurine content in different brain areas of adult male rats