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| Content Provider | Springer Nature Link |
|---|---|
| Author | Zuloaga, Kristen L. Zhang, Wenri Yeiser, Lauren A. Stewart, Blair Kukino, Ayaka Nie, Xiao Roese, Natalie E. Grafe, Marjorie R. Pike, Martin M. Raber, Jacob Alkayed, Nabil J. |
| Copyright Year | 2015 |
| Abstract | Vascular cognitive impairment (VCI) is the second most common cause of dementia. Reduced cerebral blood flow is thought to play a major role in the etiology of VCI. Therefore, chronic cerebral hypoperfusion has been used to model VCI in rodents. The goal of the current study was to determine the histopathological and neuroimaging substrates of neurocognitive impairments in a mouse model of chronic cerebral hypoperfusion induced by unilateral common carotid artery occlusion (UCCAO). Mice were subjected to sham or right UCCAO (VCI) surgeries. Three months later, neurocognitive function was evaluated using the novel object recognition task, Morris water maze, and contextual and cued fear-conditioning tests. Next, cerebral perfusion was evaluated with dynamic susceptibility contrast magnetic resonance imaging (MRI) using an ultra-high field (11.75 T) animal MRI system. Finally, brain pathology was evaluated using histology and T$_{2}$-weighted MRI. VCI, but not sham, mice had significantly reduced cerebral blood flow in the right vs. left cerebral cortex. VCI mice showed deficits in object recognition. T$_{2}$-weighted MRI of VCI brains revealed enlargement of lateral ventricles, which corresponded to areas of hippocampal atrophy upon histological analysis. In conclusion, our data demonstrate that the UCCAO model of chronic hypoperfusion induces hippocampal atrophy and ventricular enlargement, resulting in neurocognitive deficits characteristic of VCI. |
| Starting Page | 390 |
| Ending Page | 398 |
| Page Count | 9 |
| File Format | |
| ISSN | 18684483 |
| Journal | Translational Stroke Research |
| Volume Number | 6 |
| Issue Number | 5 |
| e-ISSN | 1868601X |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2015-06-05 |
| Publisher Place | New York |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Vascular dementia Cerebral blood flow Cognitive impairment Chronic cerebral hypoperfusion Neurosciences Neurology Cardiology Neurosurgery Vascular Surgery |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cardiology and Cardiovascular Medicine Neuroscience Neurology (clinical) |
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