NDLI: Early Brain Injury, an Evolving Frontier in Subarachnoid Hemorrhage Research

Content Provider	Springer Nature Link
Author	Fujii, Mutsumi Yan, Junhao Rolland, William B. Soejima, Yoshiteru Caner, Basak Zhang, John H.
Copyright Year	2013
Abstract	Subarachnoid hemorrhage (SAH), predominantly caused by a ruptured aneurysm, is a devastating neurological disease that has a morbidity and mortality rate higher than 50 %. Most of the traditional in vivo research has focused on the pathophysiological or morphological changes of large arteries after intracisternal blood injection. This was due to a widely held assumption that delayed vasospasm following SAH was the major cause of delayed cerebral ischemia and poor outcome. However, the results of the CONSCIOUS-1 trial implicated some other pathophysiological factors, independent of angiographic vasospasm, in contributing to the poor clinical outcome. The term early brain injury (EBI) has been coined and describes the immediate injury to the brain after SAH, before onset of delayed vasospasm. During the EBI period, a ruptured aneurysm brings on many physiological derangements such as increasing intracranial pressure, decreased cerebral blood flow, and global cerebral ischemia. These events initiate secondary injuries such as blood–brain barrier disruption, inflammation, and oxidative cascades that all ultimately lead to cell death. Given the fact that the reversal of vasospasm does not appear to improve patient outcome, it could be argued that the treatment of EBI may successfully attenuate some of the devastating secondary injuries and improve the outcome of patients with SAH. In this review, we provide an overview of the major advances in EBI after SAH research.
Starting Page	432
Ending Page	446
Page Count	15
File Format	PDF
ISSN	18684483
Journal	Translational Stroke Research
Volume Number	4
Issue Number	4
e-ISSN	1868601X
Language	English
Publisher	Springer US
Publisher Date	2013-03-08
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Subarachnoid hemorrhage Early brain injury Cerebral vasospasm Animal model Neurosciences Neurology Cardiology Neurosurgery Vascular Surgery
Content Type	Text
Resource Type	Article
Subject	Cardiology and Cardiovascular Medicine Neuroscience Neurology (clinical)

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Double Cisterna Magna Blood Injection Model of Experimental Subarachnoid Hemorrhage in Dogs

Hyperbaric Oxygen for Cerebral Vasospasm and Brain Injury Following Subarachnoid Hemorrhage

The Rabbit Shunt Model of Subarachnoid Haemorrhage

The Single and Double Blood Injection Rabbit Subarachnoid Hemorrhage Model

Smooth Muscle Phenotype Switching in Blast Traumatic Brain Injury-Induced Cerebral Vasospasm

Correlating Cerebral $^{18}$FDG PET-CT Patterns with Histological Analysis During Early Brain Injury in a Rat Subarachnoid Hemorrhage Model

Experimental Subarachnoid Hemorrhage: Double Cisterna Magna Injection Rat Model—Assessment of Delayed Pathological Effects of Cerebral Vasospasm

A Non-Human Primate Model of Aneurismal Subarachnoid Hemorrhage (SAH)

Tenascin-C Causes Neuronal Apoptosis After Subarachnoid Hemorrhage in Rats

Early Brain Injury, an Evolving Frontier in Subarachnoid Hemorrhage Research

Similar Documents

Double Cisterna Magna Blood Injection Model of Experimental Subarachnoid Hemorrhage in Dogs

Hyperbaric Oxygen for Cerebral Vasospasm and Brain Injury Following Subarachnoid Hemorrhage

The Rabbit Shunt Model of Subarachnoid Haemorrhage

The Single and Double Blood Injection Rabbit Subarachnoid Hemorrhage Model

Smooth Muscle Phenotype Switching in Blast Traumatic Brain Injury-Induced Cerebral Vasospasm

Correlating Cerebral $^{18}$FDG PET-CT Patterns with Histological Analysis During Early Brain Injury in a Rat Subarachnoid Hemorrhage Model

Experimental Subarachnoid Hemorrhage: Double Cisterna Magna Injection Rat Model—Assessment of Delayed Pathological Effects of Cerebral Vasospasm

A Non-Human Primate Model of Aneurismal Subarachnoid Hemorrhage (SAH)

Tenascin-C Causes Neuronal Apoptosis After Subarachnoid Hemorrhage in Rats

Early Brain Injury, an Evolving Frontier in Subarachnoid Hemorrhage Research