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| Content Provider | Springer Nature Link |
|---|---|
| Author | Kosaka, Y. Quillinan, N. Bond, C. T. Traystman, R. J. Hurn, P. D. Herson, P. S. |
| Copyright Year | 2012 |
| Abstract | Female sex steroids, particularly estrogens, contribute to the sexually dimorphic response observed in cerebral ischemic outcome, with females being relatively protected compared to males. Using a mouse model of cardiac arrest and cardiopulmonary resuscitation, we previously demonstrated that estrogen neuroprotection is mediated in part by the estrogen receptor β, with no involvement of estrogen receptor α. In this study, we examined the neuroprotective effect of the novel estrogen receptor, G protein-coupled estrogen receptor 1 (GPER1/GPR30). Male mice administered with the GPR30 agonist G1 exhibited significantly reduced neuronal injury in the hippocampal CA1 region and striatum. The magnitude of neuroprotection observed in G1-treated mice was indistinguishable from estrogen-treated mice, implicating GPR30 in estrogen neuroprotection. Real-time quantitative RT-PCR indicates that G1 treatment increases expression of the neuroprotective ion channel, small-conductance calcium-activated potassium channel 2. We conclude that GPR30 agonists show promise in reducing brain injury following global cerebral ischemia. |
| Starting Page | 500 |
| Ending Page | 507 |
| Page Count | 8 |
| File Format | |
| ISSN | 18684483 |
| Journal | Translational Stroke Research |
| Volume Number | 3 |
| Issue Number | 4 |
| e-ISSN | 1868601X |
| Language | English |
| Publisher | Springer-Verlag |
| Publisher Date | 2012-09-12 |
| Publisher Place | New York |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Cardiac arrest GPR30/GPER1 SK2 Cerebral ischemia G1 Neurosciences Vascular Surgery Cardiology Neurology Neurosurgery |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cardiology and Cardiovascular Medicine Neuroscience Neurology (clinical) |
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