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| Content Provider | Springer Nature Link |
|---|---|
| Author | Nakata, Masayo Nakagomi, Takayuki Maeda, Mitsuyo NakaDoi, Akiko Momota, Yoshihiro Matsuyama, Tomohiro |
| Copyright Year | 2016 |
| Abstract | Recent therapeutic advances have increased the likelihood of recanalizing the obstructed brain arteries in patients with stroke. Therefore, it is important to understand the fate of neural cells under transient ischemia/reperfusion injury. Accumulating evidence shows that neurogenesis occurs in perivascular regions following brain injury, although the precise mechanism and origin of these newborn neurons under transient ischemia/reperfusion injury remain unclear. Using a mouse model of transient brain ischemia/reperfusion injury, we found that neural stem cells (NSCs) develop within injured areas. This induction of NSCs following ischemia/reperfusion injury was observed even in response to nonlethal ischemia, although massive numbers of NSCs were induced by lethal ischemia. Immunohistochemical and immunoelectron microscopic studies indicated that platelet-derived growth factor receptor beta-positive (PDGFRβ$^{+}$) pericytes within injured areas following nonlethal ischemia began to express the NSC marker nestin as early as 3 days after transient ischemia/reperfusion. Some PDGFRβ$^{+}$ pericytes expressed the immature neuronal marker doublecortin at day 7. These findings indicate that brain pericytes are a potential source of the perivascular NSCs that generate neuronal cells under lethal and nonlethal ischemic conditions following transient ischemia/reperfusion. Thus, brain pericytes might be a target for neurogenesis mediation in patients with nonlethal and lethal ischemia following transient ischemia/reperfusion injury. |
| Starting Page | 131 |
| Ending Page | 143 |
| Page Count | 13 |
| File Format | |
| ISSN | 18684483 |
| Journal | Translational Stroke Research |
| Volume Number | 8 |
| Issue Number | 2 |
| e-ISSN | 1868601X |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2016-06-29 |
| Publisher Place | New York |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Ischemia/reperfusion Stroke Neural stem cells Neurogenesis Pericyte Neurosciences Neurology Cardiology Neurosurgery Vascular Surgery |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cardiology and Cardiovascular Medicine Neuroscience Neurology (clinical) |
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