NDLI: The Influence of Hindlimb Unloading on Bone and Muscle Tissues in Rat Model

Content Provider	Springer Nature Link
Author	Baltina, Tatyana Ahmetov, Nafis Sachenkov, Oskar Fedyanin, Artur Lavrov, Igor
Copyright Year	2016
Abstract	Numerous results indicate on interactions between muscles and bones. Thus, mechanical, genetic, endocrine, and age-related factors influence both tissues at the same time. Nevertheless, the details of physiological mechanisms of interaction between muscles and bones are still unclear. The purpose of this study was to evaluate the changes in low extremity muscles and bones during gravitational hindlimb unloading in rats. After hindlimb unloading during 7, 14, 21, and 30 days, muscles from the low extremities were collected and measured to estimate the muscle weight and perform cross-sectional analysis. Femoral bones were collected in order to evaluate weight, density, and geometrical parameters of the bone. Additionally, a test with a three-point bending was carried out to evaluate biomechanical bone properties. Results show that loss of muscle weight can be observed already at 1 week of hindlimb unloading with the maximum changes at 14 days. Changes in bone tissue showed the maximum loss of bone weight at 21 day. By 30 days of unloading, the density and rigidity of a bone were decreased; however, the most profound changes were observed in reduction of bone durability. These data support a hypothesis that the atrophy of skeletal muscles may promote the subsequent bone deterioration.
Starting Page	67
Ending Page	69
Page Count	3
File Format	PDF
ISSN	21911630
Journal	BioNanoScience
Volume Number	7
Issue Number	1
e-ISSN	21911649
Language	English
Publisher	Springer US
Publisher Date	2016-10-03
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Hindlimb unloading Muscle atrophy Bone density Rats Circuits and Systems Biological and Medical Physics, Biophysics Nanotechnology Biomaterials
Content Type	Text
Resource Type	Article
Subject	Bioengineering Biomedical Engineering

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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