NDLI: Impaired neuromotor functions in hospital laboratory workers exposed to low levels of organic solvents

Content Provider	Springer Nature Link
Author	Herpin, Guillaume Gauchard, Gérome C. Vouriot, Alexandre Hannhart, Bernard Barot, Alain Mur, Jean Marie Zmirou Navier, Denis Perrin, Philippe P.
Copyright Year	2008
Abstract	Solvents are ubiquitous in industrial societies in a wide range of processes, and long-term exposure to these organic compounds may impair neuromotor functions such as equilibrium function. However, there is limited knowledge of effects on posture and gaze control after organic solvent exposures below workplace threshold limit values. The aim of this study was to evaluate the consequences of low-level co-exposure to organic solvents on balance and gaze control in hospital laboratory workers. Twelve hospital laboratory female subjects mainly exposed to toluene and ethanol, with median exposure duration of 24 years, and 12 non-exposed female controls were submitted to posturography and oculomotricity testings including sensory organization and motor control tests and saccade and smooth pursuit tests. Although current measured exposure values to toluene and ethanol were much below workplace threshold limit values (current median exposure levels of 32.5 mg/ M$^{3}$ and 39.9 mg/m$^{3}$, respectively), exposed workers displayed a weaker balance and a less performant gaze control. They presented, on the one hand, a reduced ability to resolve sensorial conflict situations compared to controls, particularly when situations were managed by the vestibular information, and, on the other hand, longer saccadic reaction time. Organic solvents might have an impact on vestibular pathways involved in postural control and exert a depressant central pathway effect implicated in the management of oculomotor response. Evaluating balance control in sensory conflicting situations and saccadic reaction time is proposed as a way to reveal subclinical neurotoxicological effects due to low-level exposure to organic solvents.
Starting Page	185
Ending Page	196
Page Count	12
File Format	PDF
ISSN	10298428
Journal	Neurotoxicity Research
Volume Number	13
Issue Number	3-4
e-ISSN	14763524
Language	English
Publisher	Springer-Verlag
Publisher Date	2008-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Organic solvents Neurotoxicity Low-level exposure Balance control Gaze control Vestibular pathways Neurosciences Pharmaceutical Sciences/Technology Neurology Neurochemistry Pharmacology/Toxicology Neurobiology
Content Type	Text
Resource Type	Article
Subject	Neuroscience Toxicology

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