NDLI: The dopamine D$_{3}$ receptor and drug addiction

Please wait, while we are loading the content...

HIV-1 infected and immune competent mononuclear phagocytes induce quantitative alterations in neuronal dendritic arbor: Relevance for HIV-1-associated dementia

HIV-1 infected immune competent mononuclear phagocytes influence the pathways to neuronal demise

The common neurotrophin receptor p75$^{NTR}$ enhances the ability of PC12 cells to resist oxidative stress by a trkA-dependent mechanism

Apoptotic morphology does not always require caspase activity in rat cerebellar granule neurons

Neurotoxicity Research : Volume 3, Issue 4, July 2001

Neurotoxicity Research : Volume 3, Issue 3, May 2001

Neurotoxicity Research : Volume 3, Issue 2, March 2001

Neurotoxicity Research : Volume 3, Issue 1, January 2001

Neurotoxicity Research : Volume 2

Neurotoxicity Research : Volume 1

The dopamine D$_{3}$ receptor and drug addiction

Content Provider	Springer Nature Link
Author	Sokoloff, Pierre Foll, Bernard Le Perachon, Sylvie Bordet, Regis Ridray, Sophie Schwartz, Jean Charles
Copyright Year	2001
Abstract	Hedonic and reinforcing properties of drugs of abuse are closely related to brain dopamine neuron activity. All these drugs increase dopamine release in the shell of nucleus accumbens, a brain region in which neurons co-express the D$_{1}$ (D$_{1}$R) and D$_{3}$ (D$_{3}$R) dopamine receptor subtypes, that converging pharmacological, human post-mortem and genetic studies suggest to be implicated in drug addiction. The D$_{3}$R, through a cross-talk with the D$_{1}$R, is involved in induction and expression of behavioral sensitization to levodopa in rats bearing unilateral lesions of dopamine neurons. Behavioral sensitization, a cardinal feature of addiction arises from repeated administration of drugs of abuse is thought to play a role in intensification of reinforcing efficacy of these drugs observed under certain conditions. Stimulation of the D$_{3}$R also appears to enhance the reinforcing effect of cocaine in rats. By interacting with these processes, D$_{3}$R agents have potential therapeutic applications for treating drug addiction. BP 897 (N-[4-(4-(2-methoxyphenyl) piperazin-1-yl) butyl] naphtalen 2-carboxamide dichlorhydrate), a partial and highly selective D$_{3}$R agonistin vitro, behaves as an agonist or an antagonistin vivo depending on the response considered. BP 897 has the unprecedented property to reduce cocaine-seeking behavior induced by presentation of a cocaine-associated cue, without having any intrinsic reinforcing effect. As drug-associated cues maintain drug-seeking in animals and elicit craving and relapse in humans, D$_{3}$R agents like BP 897 may represent new medications for drug addiction, with minimal liability to maintaining dependence.
Starting Page	433
Ending Page	441
Page Count	9
File Format	PDF
ISSN	10298428
Journal	Neurotoxicity Research
Volume Number	3
Issue Number	5
e-ISSN	14763524
Language	English
Publisher	Springer-Verlag
Publisher Date	2001-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	nucleus accumbens shell behavioral sensitization cocaine drug-associated cues D$_{3}$ receptor Neurosciences Pharmaceutical Sciences/Technology Neurology Neurochemistry Pharmacology/Toxicology Neurobiology
Content Type	Text
Resource Type	Article
Subject	Neuroscience Toxicology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Regulation of AMPA Receptor Trafficking in the Nucleus Accumbens by Dopamine and Cocaine

Brain-derived neurotrophic factor controls dopamine D$_{3}$ receptor expression: Implications for neurodevelopmental psychiatric disorders

Homer2 gene deletion in mice produces a phenotype similar to chronic cocaine treated rats

Inhibition of Actin Polymerization Prevents Cocaine-induced Changes in Spine Morphology in the Nucleus Accumbens

The role of the dopamine transporter in cocaine abuse

Cocaine-induced behavioral sensitization in mice: effects of microinjection of dopamine d2 receptor antagonist into the nucleus accumbens.

Dopamine and glutamate dysfunctions in schizophrenia: Role of the dopamine D$_{3}$ receptor

Dopamine System Dysregulation by the Ventral Subiculum as the Common Pathophysiological Basis for Schizophrenia Psychosis, Psychostimulant Abuse, and Stress

The neurobiology of opiate tolerance, dependence and sensitization: Mechanisms of NMDA receptor-dependent synaptic plasticity

The dopamine D$_{3}$ receptor and drug addiction

Similar Documents

Regulation of AMPA Receptor Trafficking in the Nucleus Accumbens by Dopamine and Cocaine

Brain-derived neurotrophic factor controls dopamine D$_{3}$ receptor expression: Implications for neurodevelopmental psychiatric disorders

Homer2 gene deletion in mice produces a phenotype similar to chronic cocaine treated rats

Inhibition of Actin Polymerization Prevents Cocaine-induced Changes in Spine Morphology in the Nucleus Accumbens

The role of the dopamine transporter in cocaine abuse

Cocaine-induced behavioral sensitization in mice: effects of microinjection of dopamine d2 receptor antagonist into the nucleus accumbens.

Dopamine and glutamate dysfunctions in schizophrenia: Role of the dopamine D$_{3}$ receptor

Dopamine System Dysregulation by the Ventral Subiculum as the Common Pathophysiological Basis for Schizophrenia Psychosis, Psychostimulant Abuse, and Stress

The neurobiology of opiate tolerance, dependence and sensitization: Mechanisms of NMDA receptor-dependent synaptic plasticity

The dopamine D$_{3}$ receptor and drug addiction