NDLI: Antioxidant Activity, Cellular Bioavailability, and Iron and Calcium Management of Neuroprotective and Nonneuroprotective Flavones

Content Provider	Springer Nature Link
Author	Echeverry, Carolina Arredondo, Florencia Martínez, Marcela Abin Carriquiry, Juan Andrés Midiwo, Jacob Dajas, Federico
Copyright Year	2014
Abstract	Few studies have been undertaken on the relationship of the structure of flavones and neuroprotection. Previously, we described the structural determinants of the neuroprotective activity of some natural flavones in cerebellar granule neurons in culture against an oxidative insult (H$_{2}$O$_{2}$). In the present work, we analyzed anti-oxidant activity, cellular iron, and Ca$^{2+}$ levels and cellular bioavailability of neuroprotective and nonneuroprotective flavones in the same experimental paradigm. Oxidative cellular damage produced by H$_{2}$O$_{2}$ was prevented by all of the studied flavones with rather similar potency for all of them. Labile Iron Pool was neither affected by protective nor nonprotective flavones. Intracellular Ca$^{2+}$ homeostasis was not affected by protective flavones either. Nonetheless, fisetin, the nonprotective flavone, decreased Ca$^{2+}$ levels modifying Ca$^{2+}$ homeostasis. Methylation of the catechol group, although weakens anti-oxidant capacity, keeps the neuroprotective capacity with less degradation and lower toxicity, constituting promising structural alternatives as leads for the design of neuroprotective molecules.
Starting Page	31
Ending Page	42
Page Count	12
File Format	PDF
ISSN	10298428
Journal	Neurotoxicity Research
Volume Number	27
Issue Number	1
e-ISSN	14763524
Language	English
Publisher	Springer US
Publisher Date	2014-06-28
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Flavonoids Flavones Neuroprotection Anti-oxidation Neurosciences Neurology Neurochemistry Pharmacology/Toxicology Neurobiology Cell Biology
Content Type	Text
Resource Type	Article
Subject	Neuroscience Toxicology

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