NDLI: Developmental Iodine Deficiency and Hypothyroidism Impair Spatial Memory in Adolescent Rat Hippocampus: Involvement of CaMKII, Calmodulin and Calcineurin

Content Provider	Springer Nature Link
Author	Dong, Jing Liu, Wanyang Wang, Yi Hou, Yi Xu, Hongde Gong, Jian Xi, Qi Chen, Jie
Copyright Year	2009
Abstract	Developmental iodine deficiency (ID) leads to inadequate thyroid hormone that impairs learning and memory with an unclear mechanism. Here, we show that hippocampal calcium/calmodulin-dependent protein kinase II (CaMKII), calmodulin and calcineurin are implicated in the impaired spatial memory in adolescent rats following developmental ID and hypothyroidism. Three developmental rat models were created by administrating dam rats with either iodine-deficient diet or propylthiouracil (PTU, 5 or 15 ppm)-added drinking water from gestational day (GD) 6 till postnatal day (PN) 28. Then, the spatial memory to a water maze test was studied in pups before PN42. After testing periods, the latency to platform and the number of error in iodine-deficient and 15 ppm PTU-treatment groups were significantly higher than those in the controls (P < 0.05). Total and phosphorylated CaMKII, calmodulin, and calcineurin in the hippocampus were detected with both the immunohistochemistry and western blotting. Without going through water maze test, iodine-deficient and 15 ppm PTU-treatment groups showed significantly lower CaMKII and calmodulin and significantly higher calcineurin than the controls in hippocampal CA1 and CA3 regions (P < 0.05). After trials of water maze task, however, CaMKII and calmodulin were up-regulated and calcineurin was down-regulated in control group (P < 0.05), but not in iodine-deficient and 15 ppm PTU-treatment groups. Data indicate that hippocampal CaMKII, calmodulin, and calcineurin are involved in the impaired spatial memory induced by developmental ID and hypothyroidism.
Starting Page	81
Ending Page	93
Page Count	13
File Format	PDF
ISSN	10298428
Journal	Neurotoxicity Research
Volume Number	19
Issue Number	1
e-ISSN	14763524
Language	English
Publisher	Springer-Verlag
Publisher Date	2009-12-09
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Iodine deficiency Hypothyroidism Spatial memory CaMKII Calmodulin Calcineurin Cell Biology Neurobiology Pharmacology/Toxicology Neurochemistry Neurology Neurosciences
Content Type	Text
Resource Type	Article
Subject	Neuroscience Toxicology

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