NDLI: Restoration and putative protection in parkinsonism

Content Provider	Springer Nature Link
Author	Archer, Trevor Fredriksson, Anders
Copyright Year	2000
Abstract	Synergistic antiparkinsonian actions of different classes of putative therapeutic agents co-administered with a subthreshold dose of L-3,4-dihydroxy-phenylalanine (L-Dopa) (5mg/kg) in drug-naive l-methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP)-treated mice as well as the restorative actions of those compounds in suprathreshold L-Dopa-tolerant MPTP-treated mice subjected to “wearing-off” of L-Dopa efficacy were assessed in a series of experiments. The classes of compounds studied included the noncompetitive NMDA antagonists, memantine, amantadine and MK-801, the anticonvulsive and putative anticonvulsive agents, lamotrigine, FCE 26743, phenytoin, the monoamine oxidase inhibitors, L-Deprenyl, amiflamine, α-ethyltryptamine, clorgyline and phenelzine, and the α$_{2}$-adrenoceptor agonists, clonidine and guanfacine. In this final case, the restorative effects of clonidine and guanfacine were antagonised by the α$_{2}$-adrenoceptor antagonist, yohimbine, but not the α$_{1}$-adrenoceptor antagonist, prazosin. Within each class of potentially therapeutic agents a differential restorative efficacy was obtained, but the combination of different doses of apomorphine with clondine failed to restore motor activity. Finally, the neuroprotective actions of acute and subchronic administration of the nitrone spin-trapping compound, α-phenyl-tert-butyl nitrone upon the spontaneous motor behaviour and striatal dopamine concentrations of MPTP-treated mice was examined.
Starting Page	251
Ending Page	292
Page Count	42
File Format	PDF
ISSN	10298428
Journal	Neurotoxicity Research
Volume Number	2
Issue Number	2-3
e-ISSN	14763524
Language	English
Publisher	Springer-Verlag
Publisher Date	2000-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	MPTP C57 BL/6 L-Dopa Subthreshold Suprathreshold NMDA antagonists Anticonvulsive agents MAO inhibitors α$_{2}$-adrenoceptor agonists Locomotion Rearing PBN Striatum Dopamine“Wearing-off” Restoration Protection Parkinsonism Neurosciences Pharmaceutical Sciences/Technology Neurology Neurochemistry Pharmacology/Toxicology Neurobiology
Content Type	Text
Resource Type	Article
Subject	Neuroscience Toxicology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Neurobehavioural deficits following postnatal iron overload: I spontaneous motor activity

Delayed Exercise-Induced Functional and Neurochemical Partial Restoration Following MPTP

Physical Exercise Attenuates MPTP-Induced Deficits in Mice

Strategies for the protection of dopaminergic neurons against neurotoxicity

Melatonin fails to protect against long-term MPTP-Induced dopamine depletion in mouse striatum

Effects of acute administration of DA agonists on locomotor activity: MPTP versus neonatal intracerebroventricular 6-OHDA treatment

Intranasal and Subcutaneous Administration of Dopamine D3 Receptor Agonists Functionally Restores Nigrostriatal Dopamine in MPTP-Treated Mice

Strain-dependent recovery of open-field behavior and striatal dopamine deficiency in the mouse MPTP model of Parkinson’s disease

Histamine H$_{3}$ receptor ligands modulate L-dopa-evoked behavioral responses and L-dopa-derived extracellular dopamine in dopamine-denervated rat striatum

Restoration and putative protection in parkinsonism

Similar Documents

Neurobehavioural deficits following postnatal iron overload: I spontaneous motor activity

Delayed Exercise-Induced Functional and Neurochemical Partial Restoration Following MPTP

Physical Exercise Attenuates MPTP-Induced Deficits in Mice

Strategies for the protection of dopaminergic neurons against neurotoxicity

Melatonin fails to protect against long-term MPTP-Induced dopamine depletion in mouse striatum

Effects of acute administration of DA agonists on locomotor activity: MPTP versus neonatal intracerebroventricular 6-OHDA treatment

Intranasal and Subcutaneous Administration of Dopamine D3 Receptor Agonists Functionally Restores Nigrostriatal Dopamine in MPTP-Treated Mice

Strain-dependent recovery of open-field behavior and striatal dopamine deficiency in the mouse MPTP model of Parkinson’s disease

Histamine H$_{3}$ receptor ligands modulate L-dopa-evoked behavioral responses and L-dopa-derived extracellular dopamine in dopamine-denervated rat striatum

Restoration and putative protection in parkinsonism