NDLI: Metabolic Control Analysis in a Cellular Model of Elevated MAO-B: Relevance to Parkinson’s Disease

Content Provider	Springer Nature Link
Author	Mallajosyula, Jyothi K. Chinta, Shankar J. Rajagopalan, Subramanian Nicholls, David G. Andersen, Julie K.
Copyright Year	2009
Abstract	We previously demonstrated that spare respiratory capacity of the TCA cycle enzyme alpha-ketoglutarate dehydrogenase (KGDH) was completely abolished upon increasing levels of MAO-B activity in a dopaminergic cell model system (Kumar et al., J Biol Chem 278:46432–46439, 2003). MAO-B mediated increases in H$_{2}$O$_{2}$ also appeared to result in direct oxidative inhibition of both mitochondrial complex I and aconitase. In order to elucidate the contribution that each of these components exerts over metabolic respiratory control as well as the impact of MAO-B elevation on their spare respiratory capacities, we performed metabolic respiratory control analysis. In addition to KGDH, we assessed the activities and substrate-mediated respiration of complex I, pyruvate dehydrogenase (PDH), succinate dehydrogenase (SDH), and mitochondrial aconitase in the absence and presence of complex-specific inhibitors in specific and mixed substrate conditions in mitochondria from our MAO-B elevated cells versus controls. Data from this study indicates that Complex I and KGDH are the most sensitive to inhibition by MAO-B mediated H$_{2}$O$_{2}$ generation, and could be instrumental in determining the fate of mitochondrial metabolism in this cellular PD model system.
Starting Page	186
Ending Page	193
Page Count	8
File Format	PDF
ISSN	10298428
Journal	Neurotoxicity Research
Volume Number	16
Issue Number	3
e-ISSN	14763524
Language	English
Publisher	Springer-Verlag
Publisher Date	2009-03-05
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Mitochondrial dysfunction Monoamine oxidase B Hydrogen peroxide Krebs cycle enzymes Metabolic control analysis Reactive oxygen species Neurobiology Pharmacology/Toxicology Neurochemistry Neurology Pharmaceutical Sciences/Technology Neurosciences
Content Type	Text
Resource Type	Article
Subject	Neuroscience Toxicology

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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