NDLI: Common efficacy of psychotropic drugs in restoring stress-induced impairment of prefrontal plasticity

Content Provider	Springer Nature Link
Author	Dupin, Nathalie Mailliet, FranÇois Rocher, Cyril Kessal, Karima Spedding, Michael Jay, Therese M.
Copyright Year	2006
Abstract	We recently Investigated the effects of stress on synaptic plasticity in the prefrontal cortex, namely the prelimbic area or the apparent homologue of the primate subgenual prefrontal cortex in humans where most of the hippocampal terminal fields are localized. Exposure to an acute stress causes a remarkable and long-lasting inhibition of long term potentiation (LTP) in the frontal cortex evoked by stimulation of hippocampal outflow and this impairment is prevented by the glucocorticoid receptor antagonist mifepristone. Thus, the frontal cortex is also a target for glucocorticoids Involved In the stress response. Current data show that antidepressants of various types,i.e., tianeptine and fluoxetine, at doses normally used In antidepressant testing, restore LTP Impaired by prior acute stress. Interestingly, dozapine administered in a similar way after stress rapidly reverses the stress-induced impairment of LTP at doses which do not affect LTP alone. This stress paradigm highlights comorbidity for both etiology and treatment of psychiatric disorders like depression and schizophrenia. Restoring appropriate cognitive functions in circuits associated with dysfunctions in coping with stress may be proposed as a new systems-level approach to drug discovery and development We are presently investigating the involvement of signalling molecules in producing these plastic changes.
Starting Page	193
Ending Page	198
Page Count	6
File Format	PDF
ISSN	10298428
Journal	Neurotoxicity Research
Volume Number	10
Issue Number	3-4
e-ISSN	14763524
Language	English
Publisher	Springer-Verlag
Publisher Date	2006-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Psychotropics Prefrontal cortex Plasticity Stress Hippocampus Long term potentiation Glucocorticoids Mifepristone Clozapine Depression Schizophrenia Cognition Neurosciences Pharmaceutical Sciences/Technology Neurology Neurochemistry Pharmacology/Toxicology Neurobiology
Content Type	Text
Resource Type	Article
Subject	Neuroscience Toxicology

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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