NDLI: Safety Assessment of Lactobacillus plantarum 423 and Enterococcus mundtii ST4SA Determined in Trials with Wistar Rats

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Safety Assessment of Lactobacillus plantarum 423 and Enterococcus mundtii ST4SA Determined in Trials with Wistar Rats

Content Provider	Springer Nature Link
Author	Ramiah, K. Doeschate, K. Smith, Rob Dicks, Leon M. T.
Copyright Year	2009
Abstract	Colonization of Lactobacillus plantarum 423 and Enterococcus mundtii ST4SA in the gastro-intestinal tract was determined by using Wistar rats as model. The strains were administered through intragastric gavage over 14 days. FISH with strain-specific oligonucleotide probes indicated that Lact. plantarum 423 adhered to the surfaces of the ileum and the cecum. Enterococcus mundtii ST4SA, on the other hand, adhered to the surfaces of the cecum and colon. Results obtained by DGGE have shown that strains 423 and ST4SA excluded Enterobacteriaceae, but not lactic acid bacteria, from the cecum and colon. No signs of perforation of epithelial cells by strains 423 and ST4SA were detected. The spleen and liver appeared healthy and blood counts were normal, suggesting that the strains are not pathogenic. Both strains produce antimicrobial peptides active against a number of pathogens and may be considered as probiotics.
Starting Page	15
Ending Page	23
Page Count	9
File Format	PDF
ISSN	18671306
Journal	Probiotics and Antimicrobial Proteins
Volume Number	1
Issue Number	1
e-ISSN	18671314
Language	English
Publisher	Springer-Verlag
Publisher Date	2009-03-21
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Lactic acid bacteria Safety assessment In vivo Chemistry/Food Science Microbiology Applied Microbiology Protein Science
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Molecular Medicine Microbiology

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Safety Assessment of Lactobacillus plantarum 423 and Enterococcus mundtii ST4SA Determined in Trials with Wistar Rats

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