NDLI: Significant roles of microtubules in mature striated muscle deduced from the correlation between tubulin and its molecular chaperone αB-crystallin in rat muscles

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Significant roles of microtubules in mature striated muscle deduced from the correlation between tubulin and its molecular chaperone αB-crystallin in rat muscles

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The Journal of Physiological Sciences : Volume 59, Issue 2, March 2009

The Journal of Physiological Sciences : Volume 59, Issue 1, January 2009

Significant roles of microtubules in mature striated muscle deduced from the correlation between tubulin and its molecular chaperone αB-crystallin in rat muscles

Content Provider	Springer Nature Link
Author	Jee, Hyunseok Sakurai, Takashi Kawada, Shigeo Ishii, Naokata Atomi, Yoriko
Copyright Year	2009
Abstract	To elucidate the significance of cytoskeletal microtubule networks in striated muscles, we analyzed correlation between the content of tubulin (building block of microtubules) and αB-crystallin (a molecular chaperone for tubulin) in a variety of striated muscles expressing different myosin heavy-chain (MHC) isoforms. The content of both tubulin and αB-crystallin was larger in MHC-I dominant soleus muscle and in MHC-α dominant cardiac (atrium and ventricle) muscles; intermediate in MHC-IId dominant masseter, tongue, and diaphragm muscles; and smaller in MHC-IIb dominant plantaris, gastrocnemius, psoas, extensor digitorum longus, and tibialis anterior muscles. Since the muscles of slow-type MHC (MHC-I/α) show the most economical features in their function and metabolism, which suit for continuous activity required to sustain posture and blood pumping, the present results afforded additional support to our hypothesis that microtubule networks transduce mechanical environmental demands to morphological and biochemical responses that eventually evolve adaptive transformation in the function and metabolism of the mature muscles. The comparison of tubulin/αB-crystalline ratios across the muscles of varied MHC isoforms further suggested that mechanical stress fluctuating at the rhythmic frequency of walking and breathing efficiently activates the hypothesized dynamic function of microtubules.
Starting Page	149
Ending Page	155
Page Count	7
File Format	PDF
ISSN	18806546
Journal	The Journal of Physiological Sciences
Volume Number	59
Issue Number	3
e-ISSN	18806562
Language	English
Publisher	Springer Japan
Publisher Date	2009-03-24
Publisher Place	Japan
Access Restriction	Subscribed
Subject Keyword	Heat shock protein Adaptation Cytoskeleton Myosin heavy chain Muscle Neurobiology Cell Physiology Animal Physiology Animal Biochemistry Neurosciences Human Physiology
Content Type	Text
Resource Type	Article
Subject	Physiology

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