NDLI: Involvement of receptor-interacting protein 140 in estrogen-mediated osteoclasts differentiation, apoptosis, and bone resorption

Content Provider	Springer Nature Link
Author	Piao, Hongying Chu, Xiaojie Lv, Wentao Zhao, Yan
Copyright Year	2016
Abstract	Estrogen withdrawal following menopause results in an increase of osteoclasts formation and bone resorption, which is one of the most important mechanisms of postmenopausal osteoporosis. Recently, growing evidence has suggested that receptor-interacting protein 140 was implicated in estrogen-regulated metabolic disease, including fat metabolism and lipid metabolism. However, little is known regarding the role of receptor-interacting protein 140 in the regulation of bone metabolic by estrogen. In the present study, Western blotting disclosed that estrogen brings a significant increasing expression of receptor-interacting protein 140 in osteoclasts, but not in osteoblasts and bone marrow mesenchymal stem cells. Furthermore, analysis of TRAP staining and bone resorption assay showed that depletion of receptor-interacting protein 140 could significantly alleviate the inhibitory effects of estrogen on osteoclasts formation and bone resorption activity. Moreover, estrogen could induce osteoclasts apoptosis by increasing receptor-interacting protein 140 expression through the Fas/FasL pathway. Taken together, receptor-interacting protein 140 might be a critical player in estrogen-mediated osteoclastogenesis and bone resorption.
Starting Page	141
Ending Page	150
Page Count	10
File Format	PDF
ISSN	18806546
Journal	The Journal of Physiological Sciences
Volume Number	67
Issue Number	1
e-ISSN	18806562
Language	English
Publisher	Springer Japan
Publisher Date	2016-03-26
Publisher Place	Tokyo
Access Restriction	Subscribed
Subject Keyword	RIP140 Estrogen Osteoporosis Osteoclast Human Physiology Neurosciences Animal Biochemistry Animal Physiology Cell Physiology Neurobiology
Content Type	Text
Resource Type	Article
Subject	Physiology

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