NDLI: Variable open-end wave reflection in the pulmonary arteries of anesthetized sheep

Content Provider	Springer Nature Link
Author	Dwyer, Nathan Yong, Ah Chot Kilpatrick, David
Copyright Year	2011
Abstract	The aim of this study was to re-evaluate wave reflection in the healthy pulmonary arteries of sheep utilizing the time-domain-based method of wave intensity analysis. A thorough understanding of patterns of wave reflection during health and disease may provide future sensitive markers of early pulmonary vascular disease. Wave intensity was calculated from the simultaneous acquisition of proximal pulmonary arterial pressure and velocity in 12 anesthetized open-chest sheep. Normal pulmonary arterial wave speed was 2.1 ± 0.3 m s$^{−1}$. The incident forward compression wave generated by right ventricular systole was reflected in an open-end manner as a backward expansion wave from a site 3 cm downstream, corresponding to the main pulmonary bifurcation, and in a closed-end manner as a backward compression wave from a site 21 cm downstream, corresponding to the pulmonary microcirculation. The proximal open-end reflection site was not present throughout the entire cardiac cycle. Wave reflection was minimal with only 1% of the incident forward compression wave energy reflected as a backward expansion wave and 2% as a backward compression wave. The normal pulmonary artery in open-chest sheep is characterized by variable proximal open-end reflection from the main pulmonary bifurcation and fixed closed-end reflection from the microcirculation, generating backward-travelling waves of minimal intensity.
Starting Page	21
Ending Page	28
Page Count	8
File Format	PDF
ISSN	18806546
Journal	The Journal of Physiological Sciences
Volume Number	62
Issue Number	1
e-ISSN	18806562
Language	English
Publisher	Springer Japan
Publisher Date	2011-11-20
Publisher Place	Japan
Access Restriction	Subscribed
Subject Keyword	Hemodynamics Lung Pulmonary artery Wave intensity analysis Wave reflection Wave speed Neurobiology Cell Physiology Animal Physiology Neurosciences Animal Biochemistry Human Physiology
Content Type	Text
Resource Type	Article
Subject	Physiology

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