NDLI: Contribution of quantitative changes in individual ionic current systems to the embryonic development of ventricular myocytes: a simulation study

Content Provider	Springer Nature Link
Author	Okubo, Chikako Sano, Hitomi I. Naito, Yasuhiro Tomita, Masaru
Copyright Year	2013
Abstract	Early embryonic rodent ventricular cells exhibit spontaneous action potential (AP), which disappears in later developmental stages. Here, we used 3 mathematical models—the Kyoto, Ten Tusscher–Panfilov, and Luo–Rudy models—to present an overview of the functional landscape of developmental changes in embryonic ventricular cells. We switched the relative current densities of 9 ionic components in the Kyoto model, and 160 of 512 representative combinations were predicted to result in regular spontaneous APs, in which the quantitative changes in Na$^{+}$ current (I $_{Na}$) and funny current (I $_{f}$) made large contributions to a wide range of basic cycle lengths. In all three models, the increase in inward rectifier current (I $_{K1}$) before the disappearance of I $_{f}$ was predicted to result in abnormally high intracellular Ca$^{2+}$ concentrations. Thus, we demonstrated that the developmental changes in APs were well represented, as I $_{Na}$ increased before the disappearance of I $_{f}$, followed by a 10-fold increase in I $_{K1}$.
Starting Page	355
Ending Page	367
Page Count	13
File Format	PDF
ISSN	18806546
Journal	The Journal of Physiological Sciences
Volume Number	63
Issue Number	5
e-ISSN	18806562
Language	English
Publisher	Springer Japan
Publisher Date	2013-06-13
Publisher Place	Tokyo
Access Restriction	Subscribed
Subject Keyword	Computer simulation Ion channels Cardiac ventricular cells Development Electrophysiology Spontaneous activity Human Physiology Neurosciences Animal Biochemistry Animal Physiology Cell Physiology Neurobiology
Content Type	Text
Resource Type	Article
Subject	Physiology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in