NDLI: Identification of a resistant protein from scallop shell extract and its bile acid-binding activity

Content Provider	Springer Nature Link
Author	Fukuda, Manabu Takahashi, Kohji Ohkawa, Chiharu Sasaki, Yuya Hasegawa, Yasushi
Copyright Year	2013
Abstract	In this study, we showed that feeding rats the organic extract of scallop shells (scallop shell extract) caused a decrease in the weights of white adipose tissues in rats fed a high-fat diet. In addition, the cholesterol concentration in the serum of rats that received a diet containing scallop shell extract was significantly lower than that in the serum of rats on the control diet. Feeding this scallop shell extract to rats increased the fecal weight as well as the fecal excretion of bile acids. The amino acid composition of the feces from rats fed the scallop shell extract was different from that of feces from rats fed the control diet, and treatment of the extract with pepsin and pancreatin identified a protein with a molecular weight of 90 kDa (90-kDa protein) as one of the indigestible proteins. Interestingly the 90-kDa protein was found to be identical to a free radical-scavenging protein we previously identified and showed the ability to bind bile acids. These results suggest that indigestible proteins (resistant proteins) in the scallop shell extract, including the 90-kDa protein, inhibit the absorption of bile acid by binding to it and cause increased excretion of fecal bile acid, which subsequently may decrease the serum cholesterol level.
Starting Page	1017
Ending Page	1025
Page Count	9
File Format	PDF
ISSN	09199268
Journal	Fisheries Science
Volume Number	79
Issue Number	6
e-ISSN	14442906
Language	English
Publisher	Springer Japan
Publisher Date	2013-10-18
Publisher Place	Tokyo
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cholesterol Dietary fiber Resistant protein Scallop shell Fish & Wildlife Biology & Management Freshwater & Marine Ecology Food Science
Content Type	Text
Resource Type	Article
Subject	Aquatic Science

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