NDLI: Inhibition of Murine Norovirus and Feline Calicivirus by Edible Herbal Extracts

Content Provider	Springer Nature Link
Author	Seo, Dong Joo Choi, Changsun
Copyright Year	2016
Abstract	Human noroviruses (HuNoVs) cause foodborne and waterborne viral gastroenteritis worldwide. Because HuNoV culture systems have not been developed thus far, no available medicines or vaccines preventing infection with HuNoVs exist. Some herbal extracts were considered as phytomedicines because of their bioactive components. In this study, the inhibitory effects of 29 edible herbal extracts against the norovirus surrogates murine norovirus (MNV) and feline calicivirus (FCV) were examined. FCV was significantly inhibited to 86.89 ± 2.01 and 48.71 ± 7.38% by 100 μg/mL of Camellia sinensis and Ficus carica, respectively. Similarly, ribavirin at a concentration of 100 μM significantly reduced the titer of FCV by 77.69 ± 10.40%. Pleuropterus multiflorus (20 μg/mL) showed antiviral activity of 53.33 ± 5.77, and 50.00 ± 16.67% inhibition was observed after treatment with 20 μg/mL of Alnus japonica. MNV was inhibited with ribavirin by 59.22 ± 16.28% at a concentration of 100 μM. Interestingly, MNV was significantly inhibited with 150 µg/mL Inonotus obliquus and 50 μg/mL Crataegus pinnatifida by 91.67 ± 5.05 and 57.66 ± 3.36%, respectively. Treatment with 20 µg/mL Coriandrum sativum slightly reduced MNV by 45.24 ± 4.12%. The seven herbal extracts of C. sinensis, F. carica, P. multiflorus, A. japonica, I. obliquus, C. pinnatifida, and C. sativum may have the potential to control noroviruses without cytotoxicity.
Starting Page	35
Ending Page	44
Page Count	10
File Format	PDF
ISSN	18670334
Journal	Food and Environmental Virology
Volume Number	9
Issue Number	1
e-ISSN	18670342
Language	English
Publisher	Springer US
Publisher Date	2016-11-02
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Norovirus Murine norovirus (MNV) Feline calicivirus (FCV) Inhibition Herbal extract Virology Food Science Chemistry/Food Science
Content Type	Text
Resource Type	Article
Subject	Virology Health, Toxicology and Mutagenesis Epidemiology Food Science

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