NDLI: The role of slow and fast protein motions in allosteric interactions

Content Provider	Springer Nature Link
Author	Tzeng, Shiou Ru Kalodimos, Charalampos G.
Copyright Year	2015
Abstract	Allostery is fundamentally thermodynamic in nature. Long-range communication in proteins may be mediated not only by changes in the mean conformation with enthalpic contribution but also by changes in dynamic fluctuations with entropic contribution. The important role of protein motions in mediating allosteric interactions has been established by NMR spectroscopy. By using CAP as a model system, we have shown how changes in protein structure and internal dynamics can allosterically regulate protein function and activity. The results indicate that changes in conformational entropy can give rise to binding enhancement, binding inhibition, or have no effect in the expected affinity, depending on the magnitude and sign of enthalpy–entropy compensation. Moreover, allosteric interactions can be regulated by the modulation a low-populated conformation states that serve as on-pathway intermediates for ligand binding. Taken together, the interplay between fast internal motions, which are intimately related to conformational entropy, and slow internal motions, which are related to poorly populated conformational states, can regulate protein activity in a way that cannot be predicted on the basis of the protein’s ground-state structure.
Starting Page	251
Ending Page	255
Page Count	5
File Format	PDF
ISSN	18672450
Journal	Biophysical Reviews
Volume Number	7
Issue Number	2
e-ISSN	18672469
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2015-04-25
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	NMR spectroscopy Catabolite activator protein Cyclic nucleotide-binding Biochemistry Biophysics and Biological Physics Cell Biology Membrane Biology Biological Techniques Nanotechnology
Content Type	Text
Resource Type	Article
Subject	Structural Biology Molecular Biology Biophysics

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