NDLI: Cerebellar Mild Iron Accumulation in a Subset of FMR1 Premutation Carriers with FXTAS

Content Provider	Springer Nature Link
Author	Rogers, Hailee Ariza, Jeanelle Monterrubio, Angela Hagerman, Paul Martínez Cerdeño, Verónica
Copyright Year	2016
Abstract	Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disorder associated with premutation alleles of the FMR1 gene. Iron is essential for many facets of cell metabolism in the brain but when altered is likely to contribute to the development of neurodegenerative diseases. We previously reported that iron accumulates in the choroid plexus and the putamen in FXTAS and that the level and distribution of key iron-binding proteins are also altered, suggesting a potential alteration of iron metabolism in the brain. Here, we hypothesize that iron metabolism is also altered in the FXTAS cerebellum. To test this hypothesis, we used cerebellum samples collected from FXTAS and control subjects and measured the amount of iron contained within the cerebellar cortex and dentate nucleus. We found that the number of iron deposits increased in the cerebellum only in a subset of cases of FXTAS. This accumulation is likely to be mediated by factors other than or in addition to CGG-repeat coupled pathology. Thus, iron deposition in the cerebellum cannot be used as a hallmark of FXTAS pathogenesis.
Starting Page	641
Ending Page	644
Page Count	4
File Format	PDF
ISSN	14734222
Journal	The Cerebellum
Volume Number	15
Issue Number	5
e-ISSN	14734230
Language	English
Publisher	Springer US
Publisher Date	2016-06-04
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	FXTAS Fragile X tremor ataxia iron cerebellum Purkinje cells human Neurosciences Neurology Neurobiology
Content Type	Text
Resource Type	Article
Subject	Neurology Neurology (clinical)

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