NDLI: Specific JNK Inhibition by D-JNKI1 Protects Purkinje Cells from Cell Death in Lurcher Mutant Mouse

Content Provider	Springer Nature Link
Author	Repici, Mariaelena Zanjani, Hadi S. Gautheron, Vanessa Borsello, Tiziana Dusart, Isabelle Mariani, Jean
Copyright Year	2008
Abstract	In the Lurcher mutant mouse (+/Lc), Purkinje cells (PCs) selectively die due to the mutation that converts alanine to threonine in the glutamate ionotropic receptor GRID 2, thus resulting in a constitutively leaky cation channel. This intrinsic cell death determines a target-dependent cell death of granule cells and olivary neurons and cerebellum cytoarchitecture is severely disrupted in the adult Lurcher mutant. Although the +/Lc mutant has been widely characterized, less is known about the molecules involved in +/Lc PC death. We, here, used organotypic cerebellar slice cultures from P0 mice to investigate the role of c-jun N-terminal kinase (JNK) in +/Lc PC death by using D-JNKI1 as very specific tool to inhibit its action. Our results showed that D-JNKI1 treatment increased the number of +/Lc PC at 14 DIV of 3.6-fold. Conversely, this specific JNK inhibitor cell permeable peptide did not increase PC number in +/+ treated versus untreated cultures. These results clearly indicate that JNK plays an important role in +/Lc PC mechanism of cell death.
Starting Page	534
Ending Page	538
Page Count	5
File Format	PDF
ISSN	14734222
Journal	The Cerebellum
Volume Number	7
Issue Number	4
e-ISSN	14734230
Language	English
Publisher	Springer-Verlag
Publisher Date	2008-10-24
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cell death Lurcher mutant mouse Purkinje cells JNK Cell permeable peptide Neurology Neurobiology Neurosciences
Content Type	Text
Resource Type	Article
Subject	Neurology Neurology (clinical)

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