NDLI: Pristanic Acid Provokes Lipid, Protein, and DNA Oxidative Damage and Reduces the Antioxidant Defenses in Cerebellum of Young Rats

Please wait, while we are loading the content...

The Cerebellum : Volume 16

The Cerebellum : Volume 15

The Cerebellum : Volume 14

The Cerebellum : Volume 13

The Cerebellum : Volume 13, Issue 6, December 2014

Cerebellum Tunes the Excitability of the Motor System: Evidence from Peripheral Motor Axons

Dissecting the Links Between Cerebellum and Dystonia

Transynaptic Changes Evident in Peripheral Axonal Function After Acute Cerebellar Infarct

Sensitivity of Spatiotemporal Gait Parameters in Measuring Disease Severity in Friedreich Ataxia

Upper Body Kinematics in Patients with Cerebellar Ataxia

The Transcription Factor Cux1 in Cerebellar Granule Cell Development and Medulloblastoma Pathogenesis

Lithium Chloride Therapy Fails to Improve Motor Function in a Transgenic Mouse Model of Machado-Joseph Disease

Apoptosis of Purkinje and Granular Cells of the Cerebellum Following Chronic Ethanol Intake

Impaired Hypercarbic and Hypoxic Responses from Developmental Loss of Cerebellar Purkinje Neurons: Implications for Sudden Infant Death Syndrome

Pristanic Acid Provokes Lipid, Protein, and DNA Oxidative Damage and Reduces the Antioxidant Defenses in Cerebellum of Young Rats

A Gait Paradigm Reveals Different Patterns of Abnormal Cerebellar Motor Learning in Primary Focal Dystonias

Role of Cerebellum in Deglutition and Deglutition Disorders

Injury of the Developing Cerebellum: A Brief Review of the Effects of Endotoxin and Asphyxial Challenges in the Late Gestation Sheep Fetus

Cerebrotendinous Xanthomatosis: The Effectiveness of High-Dose Piracetam for the Treatment of Cerebellar and Sensorial Ataxia

Symposium in Honor of Ferdinando Rossi: a Passionate Journey through the Cerebellar Mysteries

The Cerebellum : Volume 13, Issue 5, October 2014

The Cerebellum : Volume 13, Issue 4, August 2014

The Cerebellum : Volume 13, Issue 3, June 2014

The Cerebellum : Volume 13, Issue 2, April 2014

The Cerebellum : Volume 13, Issue 1, February 2014

The Cerebellum : Volume 12

The Cerebellum : Volume 11

The Cerebellum : Volume 10

The Cerebellum : Volume 9

The Cerebellum : Volume 8

The Cerebellum : Volume 7

The Cerebellum : Volume 6

The Cerebellum : Volume 5

The Cerebellum : Volume 4

The Cerebellum : Volume 3

The Cerebellum : Volume 2

The Cerebellum : Volume 1

Pristanic Acid Provokes Lipid, Protein, and DNA Oxidative Damage and Reduces the Antioxidant Defenses in Cerebellum of Young Rats

Content Provider	Springer Nature Link
Author	Busanello, Estela Natacha Brandt Lobato, Vannessa Gonçalves Araujo Zanatta, Ângela Borges, Clarissa Günther Tonin, Anelise Miotti Viegas, Carolina Maso Manfredini, Vanusa Ribeiro, César Augusto João Vargas, Carmen Regla Souza, Diogo Onofre Gomes Wajner, Moacir
Copyright Year	2014
Abstract	Zellweger syndrome (ZS) and some peroxisomal diseases are severe inherited disorders mainly characterized by neurological symptoms and cerebellum abnormalities, whose pathogenesis is poorly understood. Biochemically, these diseases are mainly characterized by accumulation of pristanic acid (Prist) and other fatty acids in the brain and other tissues. In this work, we evaluated the in vitro influence of Prist on redox homeostasis by measuring lipid, protein, and DNA damage, as well as the antioxidant defenses and the activities of aconitase and α-ketoglutarate dehydrogenase in cerebellum of 30-day-old rats. The effect of Prist on DNA damage was also evaluated in blood of these animals. Some parameters were also evaluated in cerebellum from neonatal rats and in cerebellum neuronal cultures. Prist significantly increased malondialdehyde (MDA) levels and carbonyl formation and reduced sulfhydryl content and glutathione (GSH) concentrations in cerebellum of young rats. It also caused DNA strand damage in cerebellum and induced a high micronuclei frequency in blood. On the other hand, this fatty acid significantly reduced α-ketoglutarate dehydrogenase and aconitase activities in rat cerebellum. We also verified that Prist-induced increase of MDA levels was totally prevented by melatonin and attenuated by α-tocopherol but not by the nitric oxide synthase inhibitor N$^{ω}$-nitro-l-arginine methyl ester, indicating the involvement of reactive oxygen species in this effect. Cerebellum from neonate rats also showed marked alterations of redox homeostasis, including an increase of MDA levels and a decrease of sulfhydryl content and GSH concentrations elicited by Prist. Finally, Prist provoked an increase of dichlorofluorescein (DCFH) oxidation in cerebellum-cultivated neurons. Our present data indicate that Prist compromises redox homeostasis in rat cerebellum and blood and inhibits critical enzymes of the citric acid cycle that are susceptible to free radical attack. The present findings may contribute to clarify the pathogenesis of the cerebellar alterations observed in patients affected by ZS and some peroxisomal disorders in which Prist is accumulated.
Starting Page	751
Ending Page	759
Page Count	9
File Format	PDF
ISSN	14734222
Journal	The Cerebellum
Volume Number	13
Issue Number	6
e-ISSN	14734230
Language	English
Publisher	Springer US
Publisher Date	2014-08-30
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Pristanic acid Peroxisomal disorders Zellweger syndrome Redox homeostasis Rat cerebellum Neurosciences Neurology Neurobiology
Content Type	Text
Resource Type	Article
Subject	Neurology Neurology (clinical)

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Glycine Provokes Lipid Oxidative Damage and Reduces the Antioxidant Defenses in Brain Cortex of Young Rats

Pristanic acid promotes oxidative stress in brain cortex of young rats: A possible pathophysiological mechanism for brain damage in peroxisomal disorders

Experimental Evidence that Methylmalonic Acid Provokes Oxidative Damage and Compromises Antioxidant Defenses in Nerve Terminal and Striatum of Young Rats

Disruption of Mitochondrial Homeostasis by Phytanic Acid in Cerebellum of Young Rats

Acute administration of 5-oxoproline induces oxidative damage to lipids and proteins and impairs antioxidant defenses in cerebral cortex and cerebellum of young rats

5-Oxoproline Reduces Non-Enzymatic Antioxidant Defenses in vitro in Rat Brain

Neurochemical Evidence that Pristanic Acid Impairs Energy Production and Inhibits Synaptic Na$^{+}$, K$^{+}$-ATPase Activity in Brain of Young Rats

In Vitro Evidence that 2-Methylbutyrylglycine Induces Lipid Oxidative Damage and Reduces Antioxidant Defenses in Rat Cerebral Cortex

Intracerebroventricular administration of N-acetylaspartic acid impairs antioxidant defenses and promotes protein oxidation in cerebral cortex of rats

Pristanic Acid Provokes Lipid, Protein, and DNA Oxidative Damage and Reduces the Antioxidant Defenses in Cerebellum of Young Rats

Similar Documents

Glycine Provokes Lipid Oxidative Damage and Reduces the Antioxidant Defenses in Brain Cortex of Young Rats

Pristanic acid promotes oxidative stress in brain cortex of young rats: A possible pathophysiological mechanism for brain damage in peroxisomal disorders

Experimental Evidence that Methylmalonic Acid Provokes Oxidative Damage and Compromises Antioxidant Defenses in Nerve Terminal and Striatum of Young Rats

Disruption of Mitochondrial Homeostasis by Phytanic Acid in Cerebellum of Young Rats

Acute administration of 5-oxoproline induces oxidative damage to lipids and proteins and impairs antioxidant defenses in cerebral cortex and cerebellum of young rats

5-Oxoproline Reduces Non-Enzymatic Antioxidant Defenses in vitro in Rat Brain

Neurochemical Evidence that Pristanic Acid Impairs Energy Production and Inhibits Synaptic Na$^{+}$, K$^{+}$-ATPase Activity in Brain of Young Rats

In Vitro Evidence that 2-Methylbutyrylglycine Induces Lipid Oxidative Damage and Reduces Antioxidant Defenses in Rat Cerebral Cortex

Intracerebroventricular administration of N-acetylaspartic acid impairs antioxidant defenses and promotes protein oxidation in cerebral cortex of rats

Pristanic Acid Provokes Lipid, Protein, and DNA Oxidative Damage and Reduces the Antioxidant Defenses in Cerebellum of Young Rats