NDLI: An fMRI Investigation of Cerebellar Function During Verbal Working Memory in Methadone Maintenance Patients

Content Provider	Springer Nature Link
Author	Marvel, Cherie L. Faulkner, Monica L. Strain, Eric C. Mintzer, Miriam Z. Desmond, John E.
Copyright Year	2011
Abstract	Working memory is impaired in opioid-dependent individuals, yet the neural underpinnings of working memory in this population are largely unknown. Previous studies in healthy adults have demonstrated that working memory is supported by a network of brain regions that includes a cerebro-cerebellar circuit. The cerebellum, in particular, may be important for inner speech mechanisms that assist verbal working memory. This study used functional magnetic resonance imaging to examine brain activity associated with working memory in five opioid-dependent, methadone-maintained patients and five matched, healthy controls. An item recognition task was administered in two conditions: (1) a low working memory load “match” condition in which participants determined whether target letters presented at the beginning of the trial matched a probe item, and (2) a high working memory load “manipulation” condition in which participants counted two alphabetical letters forward of each of the targets and determined whether either of these new items matched a probe item. Response times and accuracy scores were not significantly different between the groups. FMRI analyses indicated that, in association with higher working memory load (“manipulation” condition), the patient group exhibited hyperactivity in the superior and inferior cerebellum and amygdala relative to that of controls. At a more liberal statistical threshold, patients exhibited hypoactivity in the left prefrontal and medial frontal/pre-SMA regions. These results indicate that verbal working memory in opioid-dependent individuals involves a disrupted cerebro-cerebellar circuit and shed light on the neuroanatomical basis of working memory impairments in this population.
Starting Page	300
Ending Page	310
Page Count	11
File Format	PDF
ISSN	14734222
Journal	The Cerebellum
Volume Number	11
Issue Number	1
e-ISSN	14734230
Language	English
Publisher	Springer-Verlag
Publisher Date	2011-09-03
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Addiction fMRI Cognition Working memory Cerebellum Methadone Neurology Neurobiology Neurosciences
Content Type	Text
Resource Type	Article
Subject	Neurology Neurology (clinical)

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