NDLI: Stomach Cancer: Interconnection between the Redox State, Activity of MMP-2, MMP-9 and Stage of Tumor Growth

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Erratum to: Separation and Characterization of Epithelial and Mesenchymal-like Murine Mammary Tumor Cells Reveals Epithelial Cell Differentiation Plasticity and Enhanced Tumorigenicity of Epithelial-enriched Tumor Cells

Cancer Microenvironment : Volume 8

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Stomach Cancer: Interconnection between the Redox State, Activity of MMP-2, MMP-9 and Stage of Tumor Growth

Content Provider	Springer Nature Link
Author	Burlaka, Anatoly P. Ganusevich, Irina I. Gafurov, Marat R. Lukin, Sergey M. Sidorik, Evgeny P.
Copyright Year	2016
Abstract	High levels of reactive oxygen (ROS) and nitrogen (RNS) species can lead to the destruction of extracellular matrix facilitating tumor progression. ROS can activate matrix metalloproteinases (MMP), damage DNA and RNA. Therefore, the levels of MMP, ROS and RNS can serve as additional prognostic markers and for the estimation of the effectiveness of tumor therapy. Concerning gastric cancer, the prognostic role of MMP, its connection with the cancer staging remains controversial and correlations between the activity of MMP with the ROS and RNS levels are insufficiently confirmed. Superoxide generation rates, nitric oxide (NO) levels, concentrations of active forms of matrix metalloproteinases MMP-2 and MMP-9 in tumor and adjacent tissues of patients with stomach cancer at different disease stages were measured by electron spin resonance (ESR) including spin-trapping and polyacrylamide gel zymography. It is shown that the activity of MMP-2 and MMP-9 in tumor tissue correlate with the superoxide radicals generation rate and NO levels (r = 0.48÷0.67, p < 0.05). The activity of MMP-2 and MMP-9 in tumor tissues and superoxide radical generation rates correlate positively with the stage of regional dissemination (r = 0.45 and 0.37, correspondingly, p < 0.05), but MMP-2 and MMP-9 activity inversely depends on distant metastatic degree of stomach cancer (r = 0.58; p < 0.05). Additionally, the feasibility of ESR to locally determine oxidative stress is demonstrated.
Starting Page	27
Ending Page	32
Page Count	6
File Format	PDF
ISSN	18752292
Journal	Cancer Microenvironment
Volume Number	9
Issue Number	1
e-ISSN	18752284
Language	English
Publisher	Springer Netherlands
Publisher Date	2016-02-23
Publisher Institution	International Cancer Microenvironment Society
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Reactive oxygen species (ROS) Matrix metalloproteinases Stomach cancer Gastric cancer Electron spin resonance (ESR) Electron paramagnetic resonance (EPR) Metastasis Cancer Research Oncology Immunology Cell Biology Biochemistry Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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Stomach Cancer: Interconnection between the Redox State, Activity of MMP-2, MMP-9 and Stage of Tumor Growth.

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