NDLI: Clinical Implications of Marker Expression of Carcinoma-Associated Fibroblasts (CAFs) in Patients with Epithelial Ovarian Carcinoma After Treatment with Neoadjuvant Chemotherapy

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Clinical Implications of Marker Expression of Carcinoma-Associated Fibroblasts (CAFs) in Patients with Epithelial Ovarian Carcinoma After Treatment with Neoadjuvant Chemotherapy

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Cancer Microenvironment : Volume 6

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Cancer Microenvironment : Volume 3

Cancer Microenvironment : Volume 2

Cancer Microenvironment : Volume 1

Clinical Implications of Marker Expression of Carcinoma-Associated Fibroblasts (CAFs) in Patients with Epithelial Ovarian Carcinoma After Treatment with Neoadjuvant Chemotherapy

Content Provider	Springer Nature Link
Author	Mhawech Fauceglia, Paulette Wang, Dan Samrao, Damanzoopinder Kim, Grace Lawrenson, Kate Meneses, Teodulo Liu, Song Yessaian, Annie Pejovic, Tanja
Copyright Year	2013
Abstract	Cancer-associated fibroblasts (CAFs) play an important role in tumor initiation and progression. The aim of this study is to explore the role of 2 CAF markers, fibroblast activated protein (FAP) and α-smooth muscle actin (αSMA), in patients with epithelial ovarian cancer (EOC) post-neoadjuvant chemotherapy. Sixty-six patients with the diagnosis of EOC treated with debulking surgery after neoadjuvant therapy were retrieved from the archives. Immunohistochemistry for FAP and αSMA antibodies were performed on paraffin-embedded tissue. Fisher’s exact test was performed to test the association between FAP and αSMA expression and disease status. Kaplan–Meier method with log-rank test was used to check the survival difference between different FAP tumor/stroma expressions. FAP stroma$^{ pos }$. expression was strongly associated with higher recurrences rate [OR: 15.95; 95 % CI: 1.521–835.206; p = 0.0072]. Cases with combined FAP stroma$^{ pos }$ and FAP tumor$^{ neg }$ had higher death rate [OR: 4.845; 95 % CI: 1.53–16.61; p = 0.0046] and higher recurrence rate [OR: 5.12; 95 % CI: 0.91–54.42; p = 0.0487] compared to all the others. Cases with combined FAP stroma$^{ neg }$ and FAP tumor$^{ neg }$ were more likely to have lower recurrence rates [OR: 0.086; 95 % CI: 0.001–0.997; p = 0.0248]. αSMA was expressed by tumor-associated stroma in 95 % of cases and by tumor cells in 9 % of cases. No statistical power was found for αSMA and disease status. Our data indicate that FAP plays an important role in predicting tumor aggressiveness in patients with EOC post-neoadjuvant therapy, and its frequent expression in this malignancy implicates that FAP targeted therapy could be a very attractive strategy.
Starting Page	33
Ending Page	39
Page Count	7
File Format	PDF
ISSN	18752292
Journal	Cancer Microenvironment
Volume Number	7
Issue Number	1-2
e-ISSN	18752284
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-11-10
Publisher Institution	International Cancer Microenvironment Society
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Cancer-associated fibroblasts (CAF) Epithelial ovarian cancer (EOC) Neoadjuvant therapy Disease outcome Cancer Research Oncology Immunology Cell Biology Biochemistry Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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