NDLI: Angiotropism, Pericytic Mimicry and Extravascular Migratory Metastasis in Melanoma: An Alternative to Intravascular Cancer Dissemination

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Angiotropism, Pericytic Mimicry and Extravascular Migratory Metastasis in Melanoma: An Alternative to Intravascular Cancer Dissemination

Content Provider	Springer Nature Link
Author	Lugassy, Claire Zadran, Sohila Bentolila, Laurent A. Wadehra, Madhuri Prakash, Roshini Carmichael, S. Thomas Kleinman, Hynda K. Péault, Bruno Larue, Lionel Barnhill, Raymond L.
Copyright Year	2014
Abstract	For more than 15 years, angiotropism in melanoma has been emphasized as a marker of extravascular migration of tumor cells along the abluminal vascular surface, unveiling an alternative mechanism of tumor spread distinct from intravascular dissemination. This mechanism has been termed extravascular migratory metastasis (EVMM). During EVMM, angiotropic tumor cells migrate in a ‘pericytic-like’ manner (pericytic mimicry) along the external surfaces of vascular channels, without intravasation. Through this pathway, melanoma cells may spread to nearby or more distant sites. Angiotropism is a prognostic factor predicting risk for metastasis in human melanoma, and a marker of EVMM in several experimental models. Importantly, analogies of EVMM and pericytic mimicry include neural crest cell migration, vasculogenesis and angiogenesis, and recent studies have suggested that the interaction between melanoma cells and the abluminal vascular surface induce differential expression of genes reminiscent of cancer migration and embryonic/stem cell state transitions. A recent work revealed that repetitive UV exposure of primary cutaneous melanomas in a genetically engineered mouse model promotes metastatic progression via angiotropism and migration along the abluminal vascular surface. Finally, recent data using imaging of melanoma cells in a murine model have shown the progression of tumor cells along the vascular surfaces. Taken together, these data provide support for the biological phenomenon of angiotropism and EVMM, which may open promising new strategies for reducing or preventing melanoma metastasis.
Starting Page	139
Ending Page	152
Page Count	14
File Format	PDF
ISSN	18752292
Journal	Cancer Microenvironment
Volume Number	7
Issue Number	3
e-ISSN	18752284
Language	English
Publisher	Springer Netherlands
Publisher Date	2014-10-12
Publisher Institution	International Cancer Microenvironment Society
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Angiotropism Melanoma Pericytic mimicry Extravascular migratory metastasis (EVMM) Abluminal vascular surface Neural crest cell migration Vasculogenesis and angiogenesis Laminin Epithelial-mesenchymal transition (EMT) Stem cell Pericytic recruitment Inflammation Cancer Research Oncology Immunology Cell Biology Biochemistry Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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