NDLI: Differential Inductive Signaling of CD90$^{+}$ Prostate Cancer-Associated Fibroblasts Compared to Normal Tissue Stromal Mesenchyme Cells

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Differential Inductive Signaling of CD90$^{+}$ Prostate Cancer-Associated Fibroblasts Compared to Normal Tissue Stromal Mesenchyme Cells

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Differential Inductive Signaling of CD90$^{+}$ Prostate Cancer-Associated Fibroblasts Compared to Normal Tissue Stromal Mesenchyme Cells

Content Provider	Springer Nature Link
Author	Pascal, Laura E. Ai, Junkui Vêncio, Ricardo Z. N. Vêncio, Eneida F. Zhou, Yong Page, Laura S. True, Lawrence D. Wang, Zhou Liu, Alvin Y.
Copyright Year	2011
Abstract	Prostate carcinomas are surrounded by a layer of stromal fibroblastic cells that are characterized by increased expression of CD90. These CD90$^{+}$ cancer-associated stromal fibroblastic cells differ in gene expression from their normal counterpart, CD49a$^{+}$CD90$^{lo}$ stromal smooth muscle cells; and were postulated to represent a less differentiated cell type with altered inductive properties. CD90$^{+}$ stromal cells were isolated from tumor tissue specimens and co-cultured with the pluripotent embryonal carcinoma cell line NCCIT in order to elucidate the impact of tumor-associated stroma on stem cells, and the ‘cancer stem cell.’ Transcriptome analysis identified a notable decreased induction of smooth muscle and prostate stromal genes such as PENK, BMP2 and ChGn compared to previously determined NCCIT response to normal prostate stromal cell induction. CD90$^{+}$ stromal cell secreted factors induced an increased expression of CD90 and differential induction of genes involved in extracellular matrix remodeling and the RECK pathway in NCCIT. These results suggest that, compared to normal tissue stromal cells, signaling from cancer-associated stromal cells has a markedly different effect on stem cells as represented by NCCIT. Given that stromal cells are important in directing organ-specific differentiation, stromal cells in tumors appear to be defective in this function, which may contribute to abnormal differentiation found in diseases such as cancer.
Starting Page	51
Ending Page	59
Page Count	9
File Format	PDF
ISSN	18752292
Journal	Cancer Microenvironment
Volume Number	4
Issue Number	1
e-ISSN	18752284
Language	English
Publisher	Springer Netherlands
Publisher Date	2011-01-07
Publisher Institution	International Cancer Microenvironment Society
Publisher Place	Dordrecht
Access Restriction	Subscribed
Subject Keyword	Prostate Prostate cancer Cancer stem cell Tumor-associated stroma Reversion-inducing cysteine-rich protein with Kazal motifs (RECK) Biomedicine general Immunology Cell Biology Oncology Biochemistry Cancer Research
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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Differential Inductive Signaling of CD90+ Prostate Cancer-Associated Fibroblasts Compared to Normal Tissue Stromal Mesenchyme Cells

Original paper differential inductive signaling of cd90 + prostate cancer-associated fibroblasts compared to normal (2010).

Differential Inductive Signaling of CD90+ Prostate Cancer-Associated Fibroblasts Compared to Normal Tissue Stromal Mesenchyme Cells

Reversion-inducing cysteine-rich protein with Kazal motifs gene expression and its clinical significance in peripheral T-cell lymphoma.

Keratinization-associated miR-7 and miR-21 Regulate Tumor Suppressor Reversion-inducing Cysteine-rich Protein with Kazal Motifs (RECK) in Oral Cancer*

Bedeutung des reversion-inducing cysteine-rich protein with Kazal motifs (RECK) für Wachstum, Beweglichkeit und Differenzierung humaner mesenchymaler Stammzellen

RECK (reversion-inducing cysteine-rich protein with Kazal motifs) regulates migration, differentiation and Wnt/β-catenin signaling in human mesenchymal stem cells

Reversion-inducing cysteine-rich protein with Kazal motifs and its regulation by glycogen synthase kinase 3 signaling in oral cancer

HDAC Inhibitors and RECK Modulate Endoplasmic Reticulum Stress in Tumor Cells

Differential Inductive Signaling of CD90$^{+}$ Prostate Cancer-Associated Fibroblasts Compared to Normal Tissue Stromal Mesenchyme Cells

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Differential Inductive Signaling of CD90+ Prostate Cancer-Associated Fibroblasts Compared to Normal Tissue Stromal Mesenchyme Cells

Original paper differential inductive signaling of cd90 + prostate cancer-associated fibroblasts compared to normal (2010).

Differential Inductive Signaling of CD90+ Prostate Cancer-Associated Fibroblasts Compared to Normal Tissue Stromal Mesenchyme Cells

Reversion-inducing cysteine-rich protein with Kazal motifs gene expression and its clinical significance in peripheral T-cell lymphoma.

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RECK (reversion-inducing cysteine-rich protein with Kazal motifs) regulates migration, differentiation and Wnt/β-catenin signaling in human mesenchymal stem cells

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