NDLI: Electrically pulsatile responsive drug delivery platform for treatment of Alzheimer’s disease

Content Provider	Springer Nature Link
Author	Wu, Li Wang, Jiasi Gao, Nan Ren, Jinsong Zhao, Andong Qu, Xiaogang
Copyright Year	2015
Abstract	Metal ions are involved in Aβ aggregate deposition and neurotoxicity via various processes, including acceleration of Aβ aggregation, disruption of normal metal homeostasis, and formation of reactive oxygen species (ROS). Although metal chelation is a promising therapeutic strategy for Alzheimer’s disease (AD), the widespread use of chelation therapy faces a significant problem; namely, it is difficult to differentiate toxic metals associated with Aβ plaques from those required by normal metal homeostasis. Furthermore, the multifactorial nature of AD and the current lack of an accepted unitary theory to account for AD neurodegeneration also restrict AD treatment through a single therapeutic strategy. This paper presents a novel bifunctional platform by integrating nonpharmacological and pharmacological cues into one system for AD treatment. This electrically responsive drug release platform, based on conducting polymer polypyrrole (PPy) incorporated with graphene-mesoporous silica nanohybrids (GSN) nanoreserviors, could realize on-demand controlled drug delivery with spatial and temporal control. Electrochemical stimulation can treat peripheral nerve injury (PNI) to stimulate neurite outgrowth. This novel system can also effectively inhibit Aβ aggregate formation, decrease cellular ROS, and protect cells from Aβ-related toxicity. The purpose of this research is to promote the design of noninvasive remote-controlled multifunctional systems for AD treatment.
Starting Page	2400
Ending Page	2414
Page Count	15
File Format	PDF
ISSN	19980124
Journal	Nano Research
Volume Number	8
Issue Number	7
e-ISSN	19980000
Language	English
Publisher	Tsinghua University Press
Publisher Date	2015-05-07
Publisher Place	Beijing
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	drug delivery graphene mesoporous silica Alzheimer’s disease amyloid β-peptides Nanotechnology Materials Science Atomic/Molecular Structure and Spectra Condensed Matter Physics Biotechnology Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Atomic and Molecular Physics, and Optics Condensed Matter Physics Electrical and Electronic Engineering

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

A cytotoxic amyloid oligomer self-triggered and NIR-enhanced amyloidosis therapeutic system

Hollow mesoporous Ia3d silica nanospheres with singleunit-cell-thick shell: Spontaneous formation and drug delivery application

Mesoporous silica nanorods intrinsically doped with photosensitizers as a multifunctional drug carrier for combination therapy of cancer

Rattle-type silica colloidal particles prepared by a surface-protected etching process

Synthesis and characterization of bionanoparticle—Silica composites and mesoporous silica with large pores

Nano-graphene oxide for cellular imaging and drug delivery

An indicator-guided photo-controlled drug delivery system based on mesoporous silica/gold nanocomposites

Elevating mitochondrial reactive oxygen species by mitochondria-targeted inhibition of superoxide dismutase with a mesoporous silica nanocarrier for cancer therapy

Development of NIR-II fluorescence image-guided and pH-responsive nanocapsules for cocktail drug delivery

Electrically pulsatile responsive drug delivery platform for treatment of Alzheimer’s disease

Similar Documents

A cytotoxic amyloid oligomer self-triggered and NIR-enhanced amyloidosis therapeutic system

Hollow mesoporous Ia3d silica nanospheres with singleunit-cell-thick shell: Spontaneous formation and drug delivery application

Mesoporous silica nanorods intrinsically doped with photosensitizers as a multifunctional drug carrier for combination therapy of cancer

Rattle-type silica colloidal particles prepared by a surface-protected etching process

Synthesis and characterization of bionanoparticle—Silica composites and mesoporous silica with large pores

Nano-graphene oxide for cellular imaging and drug delivery

An indicator-guided photo-controlled drug delivery system based on mesoporous silica/gold nanocomposites

Elevating mitochondrial reactive oxygen species by mitochondria-targeted inhibition of superoxide dismutase with a mesoporous silica nanocarrier for cancer therapy

Development of NIR-II fluorescence image-guided and pH-responsive nanocapsules for cocktail drug delivery

Electrically pulsatile responsive drug delivery platform for treatment of Alzheimer’s disease