NDLI: Targeted blue nanoparticles as photoacoustic contrast agent for brain tumor delineation

Content Provider	Springer Nature Link
Author	Ray, Aniruddha Wang, Xueding Lee, Yong Eun Koo Hah, Hoe Jin Kim, Gwangseong Chen, Thomas Orringer, Daniel A. Sagher, Oren Liu, Xiaojun Kopelman, Raoul
Copyright Year	2011
Abstract	Distinguishing a tumor from non-neoplastic tissue is a challenging task during cancer surgery. Several attempts have been made to use visible or fluorescent agents to aid in the visualization of a tumor during surgery. We describe a novel method to delineate brain tumors, using a highly sensitive photoacoustic imaging technique that is enhanced by tumor-targeting blue nanoparticles serving as a contrast agent. Experiments on phantoms and on rat brains, ex vivo, demonstrate the high sensitivity of photoacoustic imaging in delineating tumors containing contrast agent at a concentration much lower than needed for visualization by the naked eye. The limit of detection of the system for the nanoparticles is about 0.77 μg/mL in water (equivalent to 0.84 μmol/L Coomassie Blue dye). The present exploratory study suggests that photoacoustic imaging, when used with strongly optical absorbing contrast agents, could facilitate cancer surgery intraoperatively by revealing the distribution and extent of the tumor.
Starting Page	1163
Ending Page	1173
Page Count	11
File Format	PDF
ISSN	19980124
Journal	Nano Research
Volume Number	4
Issue Number	11
e-ISSN	19980000
Language	English
Publisher	Tsinghua Press
Publisher Date	2011-09-26
Publisher Place	Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Brain tumor surgery targeted nanoparticles F3 peptide Coomassie Blue dye photoacoustic imaging Biotechnology Condensed Matter Physics Materials Science Nanotechnology Biomedicine general Atomic/Molecular Structure and Spectra
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Atomic and Molecular Physics, and Optics Condensed Matter Physics Electrical and Electronic Engineering

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