NDLI: Novel carbon nanohybrids as highly efficient magnetic resonance imaging contrast agents

Content Provider	Springer Nature Link
Author	Cui, Rongli Li, Juan Huang, Huan Zhang, Mingyi Guo, Xihong Chang, Yanan Li, Min Dong, Jinquan Sun, Baoyun Xing, Gengmei
Copyright Year	2014
Abstract	Novel carbon nanohybrids based on unmodified metallofullerenes have been successfully fabricated for use as a new magnetic resonance imaging (MRI) contrast agent. The nanohybrids showed higher R $_{1}$ relaxivity and better brightening effect than Gd@C$_{82}$(OH)$_{ X }$, in T $_{1}$-weighted MR images in vivo. This is a result of the proton relaxivity from the original gadofullerenes, which retained a perfect carbon cage structure and so might completely avoid the release of Gd$^{3+}$ ions. A “secondary spin-electron transfer” relaxation mechanism was proposed to explain how the encaged Gd$^{3+}$ ions of carbon nanohybrids interact with the surrounding water molecules. This approach opens new opportunities for developing highly efficient and low toxicity MRI contrast agents.
Starting Page	1259
Ending Page	1268
Page Count	10
File Format	PDF
ISSN	19980124
Journal	Nano Research
Volume Number	8
Issue Number	4
e-ISSN	19980000
Language	English
Publisher	Tsinghua University Press
Publisher Date	2014-11-22
Publisher Place	Beijing
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	graphene oxide metallofullerene magnetic resonance imaging (MRI) nanohybrids Nanotechnology Materials Science Atomic/Molecular Structure and Spectra Condensed Matter Physics Biotechnology Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Atomic and Molecular Physics, and Optics Condensed Matter Physics Electrical and Electronic Engineering

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