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| Content Provider | Springer Nature Link |
|---|---|
| Author | Liu, Ming Gang Chen, Xue Feng He, Ting Li, Zhen Chen, Jun |
| Copyright Year | 2012 |
| Abstract | Simultaneous multisite recording using multi-electrode arrays (MEAs) in cultured and acutely-dissociated brain slices and other tissues is an emerging technique in the field of network electrophysiology. Over the past 40 years, great efforts have been made by both scientists and commercial concerns, to advance this technique. The MEA technique has been widely applied to many regions of the brain, retina, heart and smooth muscle in various studies at the network level. The present review starts from the development of MEA techniques and their uses in brain preparations, and then specifically concentrates on the use of MEA recordings in studies of synaptic plasticity at the network level in both the temporal and spatial domains. Because the MEA technique helps bridge the gap between single-cell recordings and behavioral assays, its wide application will undoubtedly shed light on the mechanisms underlying brain functions and dysfunctions at the network level that remained largely unknown due to the technical difficulties before it matured. |
| Starting Page | 409 |
| Ending Page | 422 |
| Page Count | 14 |
| File Format | |
| ISSN | 16737067 |
| Journal | Neuroscience Bulletin |
| Volume Number | 28 |
| Issue Number | 4 |
| e-ISSN | 19958218 |
| Language | English |
| Publisher | Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences |
| Publisher Date | 2012-08-07 |
| Publisher Place | Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | multi-electrode arrays acute hippocampal slices spatial neural plasticity temporal neural plasticity network electrophysiology Neurology Human Physiology Anatomy Neurosciences Anesthesiology Pain Medicine |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience Physiology Medicine |
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