NDLI: Possible novel roles of poly(rC)-binding protein 1 in SH-SY5Y neurocytes: an analysis using a dynamic Bayesian network

Content Provider	Springer Nature Link
Author	Huo, Li Rong Liang, Jian Tao Zou, Jun Hua Wang, Lan Ying Li, Qi Wang, Xiao Min
Copyright Year	2012
Abstract	Poly(rC)-binding protein 1 (PCBP1) belongs to the heterogeneous nuclear ribonucleoprotein family and participates in transcriptional and translational regulation. Previous work has identified transcripts targeted by both knockdown and overexpression of PCBP1 in SH-SY5Y neuroblastoma cells using a microarray or ProteomeLab™ protein fractionation 2-dimensions (PF-2D) and quadrupole time-of-flight mass spectrometer. The present study aimed to further determine whether these altered transcripts from major pathways (such as Wnt signaling, TGF-β signaling, cell cycling, and apoptosis) and two other genes, H2AFX and H2BFS (screened by PF-2D), have spatial relationships.The genes were studied by qRT-PCR, and dynamic Bayesian network analysis was used to rebuild the coordination network of these transcripts.PCBP1 controlled the expression or activity of the seven transcripts. Moreover, PCBP1 indirectly regulated MAP2K2, FOS, FST, TP53 and WNT7B through H2AFX or regulated these genes through SAT. In contrast, TP53 and WNT7B are regulated by other genes.The seven transcripts and PCBP1 are closely associated in a spatial interaction network.
Starting Page	282
Ending Page	290
Page Count	9
File Format	PDF
ISSN	16737067
Journal	Neuroscience Bulletin
Volume Number	28
Issue Number	3
e-ISSN	19958218
Language	English
Publisher	Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
Publisher Date	2012-07-11
Publisher Place	Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	PCBP1 RNA interference overexpression Bayesian network Neurology Anesthesiology Pain Medicine Human Physiology Anatomy Neurosciences
Content Type	Text
Resource Type	Article
Subject	Neuroscience Physiology Medicine

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