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| Content Provider | Springer Nature Link |
|---|---|
| Author | Geng, Kai Wen He, Ting Wang, Rui Rui Li, Chun Li Luo, Wen Jun Wu, Fang Fang Wang, Yan Li, Zhen Lu, Yun Fei Guan, Su Min Chen, Jun |
| Copyright Year | 2016 |
| Abstract | Ethanol is widely known for its ability to cause dramatic changes in emotion, social cognition, and behavior following systemic administration in humans. Human neuroimaging studies suggest that alcohol dependence and chronic pain may share common mechanisms through amygdala-medial prefrontal cortex (mPFC) interactions. However, whether acute administration of ethanol in the mPFC can modulate pain perception is unknown. Here we showed that bilateral microinjections of ethanol into the prelimbic and infralimbic areas of the mPFC lowered the bilateral mechanical pain threshold for 48 h without influencing thermal pain sensitivity in adult rats. However, bilateral microinjections of artificial cerebrospinal fluid into the mPFC or bilateral microinjections of ethanol into the dorsolateral PFC (also termed as motor cortex area 1 in Paxinos and Watson’s atlas of The Rat Brain. Elsevier Academic Press, Amsterdam, 2005) failed to do so, suggesting regional selectivity of the effects of ethanol. Moreover, bilateral microinjections of ethanol did not change the expression of either pro-apoptotic (caspase-3 and Bax) or anti-apoptotic (Bcl-2) proteins, suggesting that the dose was safe and validating the method used in the current study. To determine whether γ-aminobutyric acid A (GABA$_{A}$) receptors are involved in mediating the ethanol effects, muscimol, a selective GABA$_{A}$ receptor agonist, or bicuculline, a selective GABA$_{A}$ receptor antagonist, was administered alone or co-administered with ethanol through the same route into the bilateral mPFC. The results showed that muscimol mimicked the effects of ethanol while bicuculline completely reversed the effects of ethanol and muscimol. In conclusion, ethanol increases mechanical pain sensitivity through activation of GABA$_{A}$ receptors in the mPFC of rats. |
| Starting Page | 433 |
| Ending Page | 444 |
| Page Count | 12 |
| File Format | |
| ISSN | 16737067 |
| Journal | Neuroscience Bulletin |
| Volume Number | 32 |
| Issue Number | 5 |
| e-ISSN | 19958218 |
| Language | English |
| Publisher | Springer Singapore |
| Publisher Date | 2016-09-15 |
| Publisher Place | Singapore |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Ethanol mPFC Pain perception GABA$_{A}$ receptor Empathy Neurosciences Human Physiology Anesthesiology Anatomy Neurology Pain Medicine |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience Physiology Medicine |
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