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| Content Provider | Springer Nature Link |
|---|---|
| Author | Lin, Chao Wei Chen, Bi Huang, Ke Lun Dai, Yu Sen Teng, Hong Lin |
| Copyright Year | 2016 |
| Abstract | 17β-estradiol (E2) has been shown to have neuroprotective effects in different central nervous system diseases. The mechanisms underlying estrogen neuroprotection in spinal cord injury (SCI) remain unclear. Previous studies have shown that autophagy plays a crucial role in the course of nerve injury. In this study, we showed that E2 treatment improved the restoration of locomotor function and decreased the loss of motor neurons in SCI rats. Real-time PCR and western blot analysis revealed that the protective function of E2 was related to the suppression of LC3II and beclin-1 expression. Immunohistochemical study further confirmed that the immunoreactivity of LC3 in the motor neurons was down-regulated when treated with E2. In vitro studies demonstrated similar results that E2 pretreatment decreased the autophagic activity induced by rapamycin (autophagy sensitizer) and increased viability in a PC12 cell model. These results indicated that the neuroprotective effects of E2 in SCI are partly related to the suppression of excessive autophagy. |
| Starting Page | 137 |
| Ending Page | 144 |
| Page Count | 8 |
| File Format | |
| ISSN | 16737067 |
| Journal | Neuroscience Bulletin |
| Volume Number | 32 |
| Issue Number | 2 |
| e-ISSN | 19958218 |
| Language | English |
| Publisher | Springer Singapore |
| Publisher Date | 2016-02-29 |
| Publisher Place | Singapore |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | 17β-estradiol Spinal cord injury Autophagy Motor neuron Neurosciences Human Physiology Anesthesiology Anatomy Neurology Pain Medicine |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience Physiology Medicine |
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