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| Content Provider | Springer Nature Link |
|---|---|
| Author | Liu, Wen Chao Ding, Wen Long Gu, Hong Yu Chen, Ming Feng Hu, Jin Jia |
| Copyright Year | 2007 |
| Abstract | To investigate lipopolysaccharide (LPS) induced acute cerebral inflammatory damage and the therapeutic effect of ginkgolide B (BN52021).Thirty Sprague-Dawley rats were randomly divided into 3 groups (n = 10 for each group): Control group, Model group and Treatment group (treated with BN52021). LPS were injected into the fourth ventricle of rat to make a neuroinflammatory murine model. Morris water maze was used to detect the learning and memory ability of rats; changes of synapse number and subcellular ultrastructures were observed under a transmission electron microscope; OX-42 positive microglia in the brain was detected by immunohistochemical method.The average escape latency in the Treatment group were significantly shortened than that in the Model group; and the percentage of swimming distance traveled in platform quadrant accounting for total distance increased markedly. The rough endoplasmic reticulum and polyribosomes in the Treatment group were more than that in the Model group, but the number of synapses seemed to have no obvious change. The number of OX-42 positive microglia in the Treatment group decreased markedly than that in the Model group, and the grey density of OX-42-positive cells increased significantly.LPS can induce inflammatory damages to the brain, but the damage could be antagonized by BN52021. Platelet activating factor receptor antagonist may offer an effective therapy for neurodegeneration diseases.研究脂多糖(lipopolysaccharide, LPS)诱导的脑内炎性损害以及银杏内脂B(BN52021)的干预治疗效果。Sprague-Dawley 大鼠30 只, 随机分为对照组, 模型组和治疗组(BN52021 治疗), 每组10 只。 第β脑室注射LPS造模, Morris 水迷宫检测实验动物学习和记忆能力; 透射电子显微镜观察海马神经元突触数量 及亚细胞结构的变化; 免疫组织化学法检测脑内OX-42在小胶质细胞内的表达。治疗组大鼠的水迷宫逃 避潜伏期比模型组显著缩短, 平台象限游泳距离百分比显著增加; 治疗组大鼠海马神经元内质网和核糖体数量 比模型组明显增加, 突触数量则无明显变化; 治疗组大鼠脑内的OX-42阳性小胶质细胞数量比模型组明显减少, 染色灰度上升。LPS可诱导脑内炎性损害, 血小板活化因子受体拮抗剂BN52021对LPS诱导的脑内炎性 损害具有保护作用, 提示血小板活化因子受体拮抗剂对以中枢炎症为病理特征的神经退行性变有治疗作用。 |
| Starting Page | 271 |
| Ending Page | 276 |
| Page Count | 6 |
| File Format | |
| ISSN | 16737067 |
| Journal | Neuroscience Bulletin |
| Volume Number | 23 |
| Issue Number | 5 |
| e-ISSN | 19958218 |
| Language | Chinese |
| Publisher | Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences |
| Publisher Date | 2008-02-07 |
| Publisher Place | Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | brain inflammation platelet activating factor ginkgolide B ultrastructure microglia Pain Medicine Neurology Anatomy Anesthesiology Human Physiology Neurosciences |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience Physiology Medicine |
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